前列腺癌是发生在前列腺上皮的恶性肿瘤，具有较高的发生率和死亡率。本文基于前列腺癌发生发展的生物分子学机制，构建动力学模型模拟其在癌症中的作用，为前列腺癌的诊断和预后提供帮助。对于单一分子功能研究，比如信号通道、蛋白质网络，构建常微分方程组即可模拟分子变化曲线。对于多阶段的分子功能研究，可构建分段线性数学模型量化过程。动力学模型模拟计算可由MATLAB编程得到。

[1] SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2016[J].CA Cancer J Clin,2016,66(1):7.
[2] WILDHAGEN M F, KONING H D.Comparison of screen detected and clinically diagnosed prostate cancer in the european randomized study of screeing for prostate cancer,section rotterdam[J].J Urol,2005,174(1):121-125.
[3] MASSAGUE J.TGF beta in cancer[J].Cell,2008,134(2):215-230.
[4] WEI A,FAN B,ZHAO Y,et al.ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway[J].Oncotarget,2016,7(40):65374-65388.
[5] SUN X,BAO J,NELSON K C,et al.Systems modeling of anti-apoptotic pathways in prostate cancer:psychological stress triggers a synergism pattern switch in drug combination therapy[J].PLoS Comput Biol.2013,9(12):e1003358.
[6] VENKATRAMAN L,CHIA S M,NARMADA B C,et al.Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1[J].Biophys J,2012,103(5):1060-1068.
[7] HIRATA Y,AKAKURA K,HIGANO C S,et al.Quantitative mathematical modeling of PSA dynamics of prostate cancer patients treated with intermittent androgen suppression[J].J Mol Cell Biol,2012,4(3):127-132.
[8] GOLDENBERG S L,BRUCHOVSKY N,GLEAVE M E,et al.Intermittent androgen suppression in the treatment of prostate cancer:a preliminary report.[J].Urology,1995,45(5):844-845.
[9] TAO Y,GUO Q,AIHARA K.A partial differential equation model and its reduction to an ordinary differential equation model for prostate tumor growth under intermittent hormone therapy[J].J Math Biol,2014,69(4):817-838.
[10] 尹玉,李明,李昊,等.6种microRNAs在前列腺癌组织中的表达[J].中华男科学杂志,2010,16(7):599-605.
[11] 汪邈.microRNA调节TGF-β信号转导通路的数学模型及对前列腺癌的影响[D].苏州大学,2015.