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异基因间充质干细胞移植在类风湿关节炎中的研究进展
作者:颜明露  李洋 
单位:哈尔滨医科大学附属第二医院 风湿免疫科, 黑龙江 哈尔滨 150001
关键词:间充质干细胞 类风湿关节炎 免疫调节 生物材料 
分类号:R593.2
出版年·卷·期(页码):2017·36·第七期(992-995)
摘要:

间充质干细胞(MSCs)是一种具有免疫调节作用的成体干细胞,广泛分布于多种组织中。目前研究认为MSCs对于维持机体的外周免疫耐受、移植免疫耐受、胎-母免疫耐受等方面发挥了重要作用,因此,异基因MSCs移植在类风湿关节炎领域中有望成为一种新的治疗技术,国际上已经广泛开展临床试验及应用。然而有研究显示,宿主体内的免疫微环境对植入后的MSCs生物学特性及免疫调节作用有重要的影响,因此异基因MSCs移植在临床中的应用仍存在许多问题。目前一些经典的技术已遇到干细胞研究中的瓶颈,生物材料等新技术的引入对于推动干细胞相关研究具有非常重要的意义。本文就异基因MSCs移植在类风湿关节炎(RA)领域中的研究现状及临床展望进行综述。

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