Capn4和P52在结肠癌中的表达及意义-现代医学

Capn4和P52在结肠癌中的表达及意义

单位：保定市第一中心医院肿瘤内科, 河北保定 071000

分类号：R735.3

出版年·卷·期（页码）：2017·36·第七期（925-928）

摘要：

目的：探讨钙蛋白酶小亚基-1（Capn4）和核转录因子-κB2（p52）在结肠癌中的表达及临床意义，以及两者在结肠癌发生、发展过程中的相关性。方法：应用免疫组织化学方法检测70例结肠癌组织及35例癌旁正常结肠组织中Capn 4和p52的表达情况，并分析Capn 4和p52的表达与结肠癌临床病理特征的关系。结果：Capn 4及p52在结肠癌（74.3%、70.0%）中的表达明显高于癌旁正常结肠组织（22.9%、31.4%）（P<0.05），两者在结肠癌组织中表达与结肠癌的浸润深度、TNM分期以及有无淋巴结转移密切相关（P<0.05），与患者年龄、性别、分化程度无关（P>0.05），并且两者在结肠癌的发生发展中可能存在相关性（r=0.869，P<0.05）。结论：Capn 4和p52在结肠癌组织中高表达，提示两者可能与结肠癌的浸润、转移有关。两者的表达呈正相关，提示Capn 4可能通过NF-κB通路的非经典途径起作用。

Objective: To investigate the expression of calpain small subunit-1 (Capn4) and nuclear transcription factor-kappaB2 (p52) in colon cancer and its clinical significance.The correlation between Capn4 and p52 involving the development and progression of colon cancer is investigated. Methods: The expressions of Capn4 and p52 in seventy cases with colon cancer tissue and Thirty-five cases with normal colon mucosa tissueare detected by immunohistochemistry. And to analyze the relationship between the expression of them and clinicopathological features of colon cancer. Results: The expression of Capn4 and p52 in colon cancer tissue (74.3%,70.0%,respectively)is significantly higher than normal colon mucosa tissue(22.9%,31,4%,respectively)(P<0.05). The expression of Capn4 and p52 is significantly correlated with depth of infiltration,TNM staging and lymph node metastasis (P<0.05),but there is not correlated with age,sex and differentiation grade of colon cancer(P>0.05). And the expression of Capn4 and p52 is positively correlated(r=0.869,P<0.05).Conclusion: In colon cancer,Capn4 and p52 are high-expression,suggesting that Capn4 and p52 may involve the development and progression of colon cancer.The expression of both is positive correlated,suggesting that Capn4 may play a role in colon cancer by non-canonical NF-kappaB signaling pathway.

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