系统性红斑狼疮（SLE）是一种自身免疫介导的、以免疫性炎症为突出表现的、累及多系统的弥漫性结缔组织病。具体病因和发病机制，迄今为止尚不完全明确。近年来，随着免疫学和分子生物学技术的不断发展，与SLE相关的新的发病机制和抗体相继被发现。SLE的管理对于临床医师来说仍是挑战，关于该病的发病机制、生物学标志等仍有待澄清。作者将近期有关SLE发病机制、生物学标志方面的研究进展作一综述。

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