目的：探讨扭曲蛋白2介导的上皮间质转化（EMT）在卵巢癌发生、发展及预后的作用。方法：采用免疫组化法检测103例卵巢肿瘤组织中介导EMT发生的转录因子扭曲蛋白2、E-黏连蛋白及波形蛋白）的表达。对扭曲蛋白2、E-黏连蛋白及波形蛋白表达与临床病理参数之间的关系以及三者之间的相关性进行分析，采用Kaplan-Meier法分析E-黏连蛋白和波形蛋白的表达与卵巢癌患者预后之间的关系。结果：扭曲蛋白2和E-黏连蛋白的表达与卵巢癌细胞的分化程度及卵巢癌临床分期有关（P<0.05）。随着肿瘤恶性程度的增加，扭曲蛋白2在细胞质中表达和在细胞核的表达也随之增加（P=0.001）。过表达的扭曲蛋白2与E-黏连蛋白之间呈显著负相关（r²=-0.276，P=0.003），而扭曲蛋白2表达与波形蛋白表达的呈正相关（r²=0.360，P=0.02）。扭曲蛋白2阳性表达者的存活率比扭曲蛋白2阴性表达者显著降低（P=0.043）。在无病生存者中，扭曲蛋白2和波形蛋白高表达患者的无疾病进展生存均高于低表达患者（P=0.043、P=0.023）。E-黏连蛋白与总生存率无显著关联（P=0.195），与无病生存期也无明显相关性（P=0.155）。结论：扭曲蛋白2通过剥夺E-黏连蛋白的上皮细胞表型，赋予间充质细胞表型波形蛋白，从而调节EMT，促进卵巢癌的发生发展。

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