骨肉瘤组织中Livin蛋白的表达水平及与肿瘤MVD表达水平的关系-现代医学

骨肉瘤组织中Livin蛋白的表达水平及与肿瘤MVD表达水平的关系

单位：华中科技大学同济学院附属梨园医院肿瘤科, 湖北武汉 430077

分类号：R738.6

出版年·卷·期（页码）：2017·36·第六期（761-765）

摘要：

目的：探讨Livin蛋白在骨肉瘤组织中的表达及与骨肉瘤组织中肿瘤微血管密度（MVD）、临床病理特征的关系。方法：选取2013年1月～2015年12月我院病理科收集的71例术后骨肉瘤组织标本作为研究对象，采用免疫组化染色观察标本中Livin蛋白、MVD的表达情况，并探讨Livin蛋白与肿瘤组织中的MVD水平、患者的临床病理特征之间的关系。结果：71例骨肉瘤组织中，Livin蛋白阳性表达率为57.75%、MVD阳性率为60.56%，差异不具有统计学意义（P>0.05）；肉瘤组织中Livin蛋白阳性表达与MVD阳性率呈显著的正相关关系（Spearman r=0.953，P<0.001）；骨肉瘤患者的Livin蛋白阳性表达与患者的分化程度、发生肺部转移具有显著的相关性（P<0.05），Livin蛋白阳性表达与患者的年龄、性别、病灶大小、Enneking分期、病理学分型关系不显著（P>0.05）。结论：Livin蛋白在骨肉瘤组织中的表达与MVD、肿瘤分化程度、发生肺部转移具有显著的相关性。

Objective: To investigate the expression of Livin protein in osteosarcoma and the relationship between the microvessel density (MVD) and clinicopathological features of osteosarcoma. Methods: Selected 71 patients with osteosarcoma were collected from January 2013 to December 2015. The expression of Livin protein and MVD was observed by immunohistochemical staining. The relationship between Livin protein and MVD level in tumor tissue and clinicopathological features was also discussed. Results: In 71 cases of osteosarcoma, the expression rate of Livin was 57.75%, the positive rate of MVD was 60.56%, the difference was not statistically significant (P>0.05); there was a significant positive correlation between the expression of Livin protein in tumor tissue and the positive rate of MVD (Spearman, r=0.953, P<0.001); positive expression of Livin protein was correlated with the degree of differentiation and lung metastasis (P<0.05), Livin protein expression was not correlated with patients' age, gender, tumor size, Enneking stage, pathological type is not significant (P>0.05). Conclusion: The expression of Livin protein was significantly correlated with the degree of MVD, tumor differentiation and pulmonary metastasis in osteosarcoma.

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