富马酸比索洛尔对室性早搏患者血管内皮功能及自主神经功能的影响-现代医学

富马酸比索洛尔对室性早搏患者血管内皮功能及自主神经功能的影响

单位：广元市中心医院, 四川广元 628000

分类号：R453.9

出版年·卷·期（页码）：2017·36·第五期（681-685）

摘要：

目的：探讨富马酸比索洛尔对生理性室性早搏患者血管内皮功能及自主神经功能的影响。方法：选择120例室性早搏患者（无冠心病及高血压），采用随机数字表法分为对照组与观察组，每组各60例。所有患者予以常规治疗，观察组在常规治疗基础上口服富马酸比索洛尔片，对照组在常规治疗基础上口服心律平片，比较两组患者的临床疗效、自主神经功能指标和内皮功能指标。结果：治疗后观察组的总有效率显著高于对照组（χ²=9.41，P<0.05），两组的自主神经功能指标均有显著变化，且观察组的变化幅度较对照组大，差异有统计学意义（P<0.05），同时两组内皮功能指标变化幅度比较，差异有统计学意义（P<0.05）。结论：富马酸比索洛尔治疗室性早搏疗效显著，能有效改善患者心脏自主神经功能和血管内皮功能，进而有效缓解动脉痉挛，降低室性早搏的发生概率，值得临床推广和应用。

Objective: To investigate the effect of bisoprolol on endothelial function and autonomic nervous function in patients with vascular ventricular premature beat.Methods: One hundred and twenty patients with ventricular premature beat (without coronary heart disease or hypertension) were enrolled in this study and were divided into control group and observation group,60 cases in each group. All patients were treated routinely. On this basis, the observation group was treated with bisoprolol, and the control group was treated with propafenon tablet.The clinical efficacy, autonomic nerve function index and endothelial function index were observed and compared between the two groups.Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group (χ²=9.41,P<0.05).And the autonomic nervous function indexes of the two groups were significantly changed,and the change of the observation group was larger than that of the control group (P<0.05). Compared with the control group, at the same time, there was significant difference between the two groups in the changes of endothelial function(P<0.05).Conclusion: Bisoprolol has significant effect in treatment of ventricular premature beats, it effectively improves the cardiac autonomic nervous function and vascular endothelial function, and can remarkably slows light artery spasm and reduce incidence of ventricular premature beat, it is worthy of clinical popularization and application.

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