Objective: To investigate and analyze the distribution of drug use in the treatment of cerebral infarction complicated with atrial fibrillation and analyze its influencing factors.Methods: 249 cases of patients with cerebral infarction complicated with atrial fibrillation were selected from January 2012 to January 2015 in our hospital,demographic and clinical data of patients were collected,the risk of bleeding of patients was evaluated by atrial fibrillation hemorrhage score (HAS-BLED score).Results: 102 cases of patients with cerebral infarction and atrial fibrillation (40.96%) were used aspirin alone among 249 cases of patients,49cases of patients used clopidogrel alone(19.68%). 28 cases of patients were combined use of aspirin and clopidogrel(11.24%), 7 cases of patients usedlow molecular heparin(2.81%), 31 cases of patients used warfarin (12.45%),32 cases of patients were not used drug(12.85%).Treatment rate of patients with cerebral infarction complicated with atrial fibrillation was 87.15%(217 cases),significantly higher than 12.85% of the untreated rate (32 cases),the difference had statistical significance(χ²=274.900,P<0.05).Antiplatelet treatment rate(71.89%,179 cases) was significantly higher thananticoagulant treatment rate(15.26%,38cases), the difference had statistical significance(χ²=162.368,P<0.05). According to HAS-BLED score,they were divided into two groups. HAS-BLED scores ≥ 3 scores group had157 cases of patients,121 cases of which(77.07%) received antiplatelet treatment, 10 cases(6.37%)received anticoagulation treatment,26 caseswere not used drugs(16.56%);92 cases of patients were inHAS-BLED scores < 3 scores group,58 cases of which(63.04%) received antiplatelet treatment, 28 cases received anticoagulant treatment (30.43%),6 cases of were not used drugs(6.52%).Antiplatelet treatment rate and untreated rate of HAS-BLED score ≥ 3 scores group were higher than those of HAS-BLED score < 3 scores group, the difference had statistical significance(P<0.05). Conclusion: Warfarin drug use rate of anticoagulation treatment in treatment of anti thrombosis of patients with cerebral infarction complicated with atrial fibrillation is not enough, and the risk of bleeding is the main impact factor. While HAS-BLED score is goodfor bleeding risk assessment of patients with cerebral infarction and atrial fibrillation,so as to determine its antithrombotic treatment drugs.