目的：采用Meta分析的方法对FCGR2A基因rs1801274位点多态性与川崎病相关性研究进行分析。方法：截至2016年8月，计算机检索英文数据库（PubMed、EMbase）及中文数据库[中国知网（CNKI）、维普期刊资源整合服务平台（VIP）和万方数据知识服务平台（Wanfang）、中国生物医学文献服务系统（SinoMed）]中rs1801274位点基因多态性与川崎病相关性研究。采用Stata 12.0软件进行Meta分析。结果：共纳入8篇文献，包括3 724例患儿（川崎病组）和14 278例对照（对照组）。rs1801274位点基因多态性在等位基因模型（A vs G）、共显性模型（AG vs GG、AA vs GG）、显性模型（AG+AA vs GG）和隐性模型（AA vs AG+GG）比较模型下均与川崎病患病风险增加相关，合并OR值及其95%CI分别为1.387（1.299～1.480）、1.501（1.072～2.102）、1.959（1.403～2.735）、1.736（1.258～2.396）、1.397（1.174～1.661）。各研究异质性检验、Begg's检验和Egger's检验均P>0.1。结论：rs1801274位点基因多态性与川崎病相关，A等位基因是发生川崎病的危险基因。

[1] KAWASAKI T,KOSAKI F,OKAWA S,et al.A new infantile acute febrile mucocutaneous lymph node syndrome(MLNS) prevailing in Japan[J].Pediatrics,1974,54(3):271-276.
[2] TANIUCHI S,MASUDA M,TERAGUCHI M,et al.Polymorphism of Fc gamma RⅡa may affect the efficacy of gamma-globulin therapy in Kawasaki disease[J].J Clin Immunol,2005,25(4):309-313.
[3] BIEZEVELD M,GEISSLER J,MERKUS M,et al.The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease[J].Clin Exp Immunol,2007,147(1):106-111.
[4] KHOR C C,DAVILA S,BREUNIS W B,et al.Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease[J].Nat Genet,2011,43(12):1241-1246.
[5] ONOUCHI Y,OZAKI K,BURNS J C,et al.A genome-wide association study identifies three new risk loci for Kawasaki disease[J].Nat Genet,2012,44(5):517-521.
[6] 纪玉晓,张宏艳,林书祥,等.川崎病患儿FCGR2A基因单核苷酸多态性的研究[J].中国当代儿科杂志,2013,15(3):196-200.
[7] YAN Y,MA Y,LIU Y,et al.Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese[J].Hum Genet,2013,132(6):669-680.
[8] CHATZIKYRIAKIDOU A, AIDINIDOU L, GIANNOPOULOS A,et al.Absence of association of FCGR2A gene polymorphism rs1801274 with Kawasaki disease in Greek patients[J].Cardiol Young,2015,25(4):681-683.
[9] LOU J,ZHONG R,SHEN N,et al.Systematic confirmation study of GWAS-identified genetic variants for Kawasaki disease in a Chinese population[J].Sci Rep,2015,5:8194.
[10] NEWBURGER J W,TAKAHASHI M,GERBER M A,et al.Diagnosis,treatment,and long-term management of Kawasaki disease:a statement for health professionals from the Committee on Rheumatic Fever,Endocarditis,and Kawasaki Disease,Council on Cardiovascular Disease in the Young,American Heart Association[J].Pediatrics,2004,114(6):1708-1733.
[11] STANG A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol,2010,25(9):603-605.
[12] PLEASS R J,WOOF J M.Fc receptors and immunity to parasites[J].Trends Parasitol,2001,17(11):545-551.
[13] HARLEY J B,ALARCON-RIQUELME M E,et al.Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM,PXK,KIAA1542 and other loci[J].Nat Genet,2008,40(2):204-210.
[14] WARMERDAM P A,van de WINKEL J G,VLUG A,et al.A single amino acid in the second Ig-like domain of the human Fc gamma receptor Ⅱ is critical for human IgG2 binding[J].J Immunol,1991,147(4):1338-1343.
[15] SHRESTHA S,WIENER H,SHENDRE A,et al.Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response[J].Circ Cardiovasc Genet,2012,5(3):309-316.
[16] SCHNEIDER M P,LEUSEN J H,HERRMANN M,et al.The Fcγ receptor ⅡA R131H gene polymorphism is associat-ed with endothelial function in patients with hypercholesterolaemia[J].Atherosclerosis,2011,218(2):411-415.
[17] RIDKER P M,RIFAI N,ROSE L,et al.Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of firstcardiovascular events[J].N Engl J Med,2002,347(20):1557-1565.
[18] 蒋勇,赵东赤,赵梦.初始剂量静脉用丙种球蛋白治疗无反应川崎病的临床特征和预测指标[J].中华实用儿科临床杂志,2015,30(9):676-680.