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微小RNA与多发性骨髓瘤诊治的研究进展
作者:单学赟  孙乃同  王纯斌 
单位:盐城市第三人民医院, 江苏 盐城 224000
关键词:多发性骨髓瘤 微小RNA 综述 
分类号:R733.3
出版年·卷·期(页码):2017·36·第九期(1380-1383)
摘要:

微小RNA是一类无编码功能却拥有调控功能的小分子RNA,其主要是通过阻止相关基因翻译表达或直接参加降解相关基因等途径,来实现对相关靶基因进行转录后信息调控。在对多发性骨髓瘤的大量研究中发现,多发性骨髓瘤瘤细胞的增殖、凋亡及耐药等过程中均存在多个微小RNA表达异常,故微小RNA可用于协助诊断多发性骨髓瘤、评估疗效、预测预后,乃至一些微小RNA可作为将来的治疗靶点。

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