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类风湿关节炎成纤维样滑膜细胞的研究进展
作者:蔡辉  张蓓蓓 
单位:南京军区南京总医院 中西医结合科, 江苏 南京 210002
关键词:成纤维样滑膜细胞 类风湿关节炎 Toll样受体 表观遗传变异 综述 
分类号:R593.22
出版年·卷·期(页码):2017·36·第九期(1362-1366)
摘要:

成纤维样滑膜细胞(fibroblast like synoviocytes,FLS)在类风湿关节炎(rheumatoid arthritis,RA)发病中的作用越来越受到重视。针对FLS的抗风湿治疗有希望为对现有抗风湿药物应答不充分的患者带来新希望,例如Toll样受体(Toll-like receptors,TLR)拮抗剂、细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinase inhibitors,CDKi)、组蛋白去乙酰化酶抑制剂等,但应用到临床仍有许多问题需要解决。

参考文献:

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