Objective: To study the effects of different doses of metformin on blood glucose fluctuation and lower extremity vascular disease in patients with impaired glucose tolerance (IGT). Methods: a randomized, controlled, prospective study, 120 patients with 2013.4-2014.6 IGT were randomly divided into three groups of machines, A group were treated with metformin, 500 mg/time, 1 times/day, B group was given 500 mg/time, 2 times/day, C group was given 500 mg/time, 3 times/day, all patients were given such as exercise and diet intervention at the same time, 30 days for a course of treatment, a total of 3 courses of treatment, compared before and after treatment of insulin resistance, blood glucose, body weight, and were followed up for 2 years, to observe the situation of patients with lower extremity vascular disease. Results: the three groups after treatment group C blood glucose index (FPG, 2hPG and HbA1c, the blood glucose fluctuation coefficient, the highest blood glucose insulin index (FINS index), and insulin resistance, blood lipid) is the lowest, followed by B group and A group, by statistical analysis, P<0.05, comparison between groups was statistically difference in C group; after the HOMA-beta is highest, followed by B group and A group, by statistical analysis, P<0.05, comparison between groups was statistically difference; there was no significant difference in the rate of adverse reactions occurred during the treatment in the three groups (P>0.05); during 2 years of follow-up C group had no lower extremity vascular disease, B group occurred in 2 cases of lower extremity vascular disease, 4 cases occurred in the A group. Conclusion: the early use of high dose of metformin in IGT patients can effectively reduce the blood glucose fluctuations and metabolic indicators, in the prevention of lower extremity vascular disease has obvious clinical effect. |
