马来酸桂哌齐特和复方丹参注射液治疗急性脑梗死的疗效比较-现代医学

马来酸桂哌齐特和复方丹参注射液治疗急性脑梗死的疗效比较

单位：1. 青海省民和县人民医院药械科, 青海民和 810800;
2. 青海省民和县人民医院内科, 青海民和 810800

分类号：R453.9;R743.33

出版年·卷·期（页码）：2017·36·第九期（1309-1313）

摘要：

目的：探讨急性脑梗死（ACI）患者采用马来酸桂哌齐特治疗的临床效果及安全性。方法：选取我院2014年1月至2016年6月收治的120例ACI患者作为研究对象，采用随机数字表法分为研究组和对照组各60例，两组基础治疗一致，研究组给予马来酸桂哌齐特、对照组给予复方丹参注射液，治疗14 d后观察临床效果。结果：治疗后研究组的血清脑源性神经营养因子、神经生长因子水平高于对照组（P<0.05），神经元特异性烯醇化酶水平低于对照组（P<0.05），研究组的血清白细胞介素-1β、白细胞介素-6、可溶性细胞间黏附分子-1的水平低于对照组（P<0.05），研究组的美国国立卫生院卒中量表（NIHSS）评分低于对照组（P<0.05）；治疗14 d后，研究组的预后良好率71.67%高于对照组的51.67%（P<0.05）；研究组治疗过程中有1例患者出现低热、1例出现皮疹，对照组未见不良反应发生，差异无统计学意义（P>0.05）。结论：ACI患者采用马来酸桂哌齐特治疗能有效地改善神经营养、减轻炎症反应、改善神经功能缺损症状，从而提高临床效果。

Objective: To investigate the clinical effect and safety of acute cerebral infarction(ACI) patients treated with cinepazide maleate. Methods: 120 patients with ACI treated in our hospital from January 2014 to June 2016 were selected as the subjects, using random number table method, divided into the study group and the control group, 60 cases in each group, the patients in the two groups were consistent with the basic treatment, the study group was given cinepazide maleate, the control group was given compound Danshen injection,the clinical effects of treatment of 14 d were observed. Results: After treatment, the levels of serum brain-derived neurotrophic factorand nerve growth factorin the study group were higher than those in the control group (P<0.05), the level of neuron specific enolase in the study group was lower than that in the control group (P<0.05), the levels of serum interleukin-1 beta, interleukin-6 and soluble intercellular adhesion molecule-1 in the study group were lower than those in the control group (P<0.05), the National Institutes of Health Stroke Scale scores in the study group was lower than that in the control group (P<0.05). After the treatment of 14 d, the prognosis rate of the study group was 71.67%, higher than that of the control group (51.67%) (P<0.05). There were 1 case of low fever and 1 case of rash in the study group, and no adverse reactions occurred in the control group. The difference was not statistically significant (P>0.05). Conclusion: The treatment can effectively improve nerve nutrition, reduce inflammatory reaction, improve neurological function by cinepazide maleate in patients with ACI, so as to improve the clinical effect.

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