Objective: To explore the effects of total thoracoscopic cardiac arrest and open beating heart surgery on myocardial mPTP openness and CF6 expression. Methods: According to the digital table method, 56 cases of rheumatic heart disease were included in the observation group (total thoracoscopic open beating heartsurgery) or control group (total thoracoscopic cardiac arrest surgery), each group of 28 cases; the changes of mPTP opening degree and CF6 value in right atrium were measured at different time points, and the changes of myocardial injury index (lactate dehydrogenase, creatine kinase isoenzyme and troponin T) were compared between the two groups. Results: In the observation group, the duration of the operationwas longer than that in the control group, and the differences were statistically significant (P<0.05) in the time of aortic occlusion time, cardiopulmonary bypass time, ICU monitoring time, hospital stay and hospitalization cost. In the myocardial injury index, the changes of lactate dehydrogenase, creatine kinase isoenzyme and troponin T in the observation group were smaller than those in the control group. In addition, the degree of open mPTP in the observation group was smaller than that in the control group, the fluctuation of CF6 expression was smaller than that of the control group. Conclusion: Total thoracoscopic open beating heart surgery can reduce the degree of open mPTP, inhibit theexcessive expression of CF6, thereby which can reducemyocardial injury and improve the rate of postoperative recovery. |
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