肥胖儿童血清内脂素、丝氨酸蛋白酶抑制剂与糖脂代谢的相关性研究-现代医学

肥胖儿童血清内脂素、丝氨酸蛋白酶抑制剂与糖脂代谢的相关性研究

单位：1. 威海市中医院药剂科, 山东威海 264200;
2. 栖霞市人民医院检验科, 山东栖霞 264200;
3. 威海市市立医院小儿科, 山东威海 264200

分类号：R725.8

出版年·卷·期（页码）：2017·36·第三期（426-429）

摘要：

目的：探讨肥胖儿童血清内脂素和丝氨酸蛋白酶抑制剂与糖脂代谢的关系。方法：选取2010年7月至2015年12月在威海市中医院内分泌科就诊及住院的126例单纯性肥胖患儿（肥胖组）及112例超重患儿（超重组），另选择120例正常儿童（正常对照组）。测量3组儿童身高、体质量、腰围及臀围，计算体质量指数（BMI）。测定各组儿童的空腹血糖（FPG）、空腹胰岛素（FINS）和血脂指标，采用酶联免疫吸附法测定3组儿童血清中丝氨酸蛋白酶抑制剂和内脂素水平。分析3组儿童血清丝氨酸蛋白酶抑制剂、内脂素水与糖脂代谢指标的相关性。结果：肥胖组和超重组的内脂素（t=1.35，P=0.007）、丝氨酸蛋白酶抑制剂（t=1.48，P=0.04）水平均高于正常对照组，肥胖儿童的FPG（t=0.624，P=0.01）、FINS（t=1.488，P=0.02）、TC（t=1.184，P=0.013）、TG（t=0.211，P=0.009）和LDL-C（0.278，P=0.032）水平均高于超重组和正常组。肥胖组的内脂素与HDL-C呈显著正相关（r=0.49 P=0.82），与FPG（r=-0.84，P=-0.47），FINS（r=-0.21，P=-0.11）呈显著负相关。肥胖组的丝氨酸蛋白酶抑制剂与FINS（r=0.58，P=0.011），TC（r=0.31，P=0.032），TG（r=0.4，P=0.002），AI（r=0.042，P=0.047）呈显著正相关，与ISI呈负相关（r=-0.23，P=0.041）。结论：肥胖儿童中内脂素与糖代谢关系密切，与脂质的代谢关系尚须进一步研究。特异性丝氨酸蛋白酶抑制剂与脂代谢及动脉粥样硬化指数密切相关，且参与了糖代谢。

Objective: To investigate the relationship between serum visfatin, vaspin,and glucose and lipid metabolism in obsess children. Methods: A total of 126 obese children were enrolled in this trial. And 112 overweight children,120 cases of normal healthy children were selected as the control. The index such as height, weight, FPG,FINS were measured. And the body mass index BMI was calculated. The vaspin and visfatin level were collected by ELISA.Results: The level of vaspin(t=1.35,P=0.007) and visfatin(t=1.48,P=0.04) in obese children were much higher than any other groups. The level of FPG(t=0.624,P=0.01)、FINS(t=1.488,P=0.02), TC(t=1.184,P=0.013),TG(t=0.211,P=0.009) and LDL-C(0.278,P=0.032)in obese children were higher than the controls. The level of visfatin had a positive correlation with HDL-C( r=0.49 P=0.82),and a negative correlation with FPG(r=-0.84,P=-0.47),FINS(r=-0.21,P=-0.11) in obesity.The level of vaspin had positive correlation with FINS(r=0.58,P=0.011), TC(r=0.31,P=0.032), TG(r=0.4,P=0.002), AI(r=0.042,P=0.047), and had negative correlation with ISI(r=-0.23,P=0.041) in the obese children. Conclusion: Visfatin is closely related with glucose metabolism in obese children, and its relationship with lipid metabolism needs further research. Specific serine protease inhibitors are closely related with lipid metabolism and atherosclerosis index, which is involved in the metabolism of glucose.

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