患者血清IL-17水平在心肌梗死后心衰及心律失常中的筛选价值分析-现代医学

患者血清IL-17水平在心肌梗死后心衰及心律失常中的筛选价值分析

单位：1. 柳州市工人医院心血管内科, 广西柳州 545005;
2. 广西科技大学计算机科学与通信工程学院, 广西柳州 545006

分类号：R542.22

出版年·卷·期（页码）：2017·36·第三期（381-384）

摘要：

目的：评估心肌梗死患者血清IL-17水平在心肌梗死后心衰及心律失常中的筛选价值。方法：心肌梗死患者入院确诊后通过酶联免疫吸附法（ELISA）对其进行血清IL-17水平检测，对患者进行随访，记录患者心肌梗死后心衰和心率失常的发生情况，比较149例患者梗死后发生心衰（n=48）和心律失常患者（n=49）和仅有心肌梗死患者（n=52）血清IL-17水平的变化；绘制受试者工作特征曲线（ROC）分析IL-17对心肌梗死后心衰和心律失常的筛选价值。结果：心肌梗死后发生心衰者血清IL-17水平[（36.41±10.96） pg·ml^-1]和心肌梗死后心律失常者血清IL-17水平[（24.10±8.07） pg·ml^-1]显著高于仅有心肌梗死患者[（16.70±7.92） pg·ml^-1]（P<0.001）。血清IL-17在筛选心肌梗死后心衰和心律失常中的曲线下面积（AUC）分别为0.91和0.771。结论：心肌梗死后出现心衰和心律失常患者血清IL-17水平显著升高；IL-17水平在心肌梗死后心衰发生中具有一定筛选价值，而在心肌梗死后心律失常的筛选中并不理想。

Objective: To investigate the screening value of serum IL-17 levels for occurrence of heart failure or arrhythmia in patients with myocardial infarction.Methods: Serum IL-17 levels were detected by enzyme-linked immunosorbent assay(ELISA) in 149 patients with myocardial infarction only(n=52), occurrence of heart failure(n=48) or arrhythmia(n=49);ROC curve was performed to analyze the screening value of IL-17 for heart failure and arrhythmia in patients with myocardial infarction.Results:Serum levels of IL-17 in patients with heart failure after myocardial infarction [(36.41±10.96) pg·ml^-1]and with arrhythmia after myocardial infarction [(24.10±8.07) pg·ml^-1] were significantly increased than those with myocardial infarction only [(16.70±7.92) pg·ml^-1](P<0.001).The area under the curve(AUC) of serum IL-17 in the screening of heart failure and arrhythmia after myocardial infarction were 0.91 and 0.771, respectively.Conclusion:Serum levels of IL-17 in patients with heart failure after myocardial infarction and with arrhythmia after myocardial infarction are significantly increased than those with myocardial infarction only.IL-17 presents a certain screening value for occurrence of heart failure after myocardial infarction, while not ideal for screening arrhythmia after myocardial infarction.

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