Objective: To investigate the relationship between serum levels of bone protective factor (OPG) and oxidative stress in patients with type 2 diabetes mellitus (T2DM). Methods: January 2014 to December 2015, 128 patients with T2DM in Handan Central Hospital were selected. According to the bone mineral density (BMD), they were divided into 45 cases of the normal bone mass group, 42 cases of the bone mass reduction group and 41 cases of osteoporosis group, another 50 cases of healthy people were selected as the control group. Serum OPG, SOD, GSH, MDA, CAT, GSH-Px and AOPP wrer detected, and the relationship among the groups was analyzed. Results: SOD, GSH, GSH-Px in the normal bone mass group, osteopenia group and osteoporosis group were significantly higher thanthose in the control group (P<0.05). SOD, GSH-Px, CAT in the osteoporosis group were significantly lower than those of the osteopenia group and normal bone mass group (P<0.05). SOD and GSH in the osteoporosis group were significantly lower than those in the normal bone mass group (P<0.05). MDA, OPG, AOPP in the normal bone mass group, osteopenia group, osteoporosis group were significantly higher than those in the control group (P<0.05). OPG and AOPP in the osteoporosis group were significantly higher than those of osteopenia group, osteoporosis group (P<0.05). MDA in the osteoporosis group was significantly higher than that of normal bone mass group (P<0.05). Multiple stepwise regression analysis showed that OPG=-0.481 (SOD)-0.322 (GSH)+2.755 (MDA)-0.319 (GSH-Px)+1.672 (AOPP); OPG was negatively correlated with SOD, GSH, GSH-Px (P<0.05), and positively correlated with MDA, AOPP(P<0.05). Conclusion: OPG level in patients with T2DM is closely related to oxidative stress, oxidative stress may contribute to the development of diabetic osteoporosis. |
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