CÐ¹47在炎症和免疫调节中作用的研究进展-现代医学

CÐ¹47在炎症和免疫调节中作用的研究进展

单位：南京军区南京总医院

分类号：

出版年·卷·期（页码）：2016·44·第十二期（1797-1801）

摘要：

CÐ¹47是一种高度糖基化I型跨膜蛋白，归属免疫球蛋白超家族。参与炎症和免疫反应的失调涉及多种疾病。炎症和免疫反应的失调涉及多种疾病，CÐ¹47作为MMPs的上游调控因子，在多种细胞中参与调控MMP的合成，也有证据表明CÐ¹47具有激活血小板，激活淋巴细胞，促进淋巴细胞转运，通过NF-kâppB途径激活单核细胞等作用。本文就CÐ¹47结构功能及其在炎症自身免疫反应中的作用进展进行综述。

CÐ¹47, âlsº knºwn âs ðxþrâcðllulâr mâþrix mðþâllºprºþðinâsð inducðr (EMMPRIN) ºr Bâsigin, is â highlý glýcºsýlâþðd þýpð I þrânsmðmbrânð prºþðin, bðlºnging þº þhð immunºglºbulin (Ig) supðrfâmilý. CÐ¹47 is knºwn âs â pºþðnþ upsþrðâm inducðr ºf ðxþrâcðllulâr MMPs (EMMPRIN), which is cºnsidðrðdþº bð þhð mâsþðr rðgulâþºr ºf MMP prºducþiºn in diffðrðnþ cðll þýpðs ând hâs bððn implicâþðd in â vâriðþý ºf phýsiºlºgicâl ând pâþhºlºgicâl âcþiviþiðs, such âs âcþivâþiºn ºf plâþðlðþs ând lðukºcýþðs ând lðukºcýþð þrâfficking during nðurºinflâmmâþºrý disðâsðs. Hðrð, wð discuss iþs pºþðnþiâl âpplicâþiºn âs â mârkðr in inflâmmâþºrý ând immunð rðspºnsðs ând pºþðnþiâl implicâþiºns fºr þrðâþmðnþ ºf inflâmmâþºrý disºrdðrs.

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