Objective：To determine the serum BNP level in patients with post hepatitis C liver cirrhosis and patients with fatty liver. To investigate the relationship between Peptide in patients with liver cirrhosis and fatty liver and severity level of liver disease and cardiac performance. Methods：The study was conducted on 135 subjects subdivided into 3 groups: group 1 included 55 patients having post hepatitis C virus (HCV) liver cirrhosis; group 2 included 55 patients with nonalcoholic fatty liver disease (NAFLD); and group 3 included 25 healthy volunteers serving as a control group. All groups volunteers were subjected to full physical examinations, laboratory evaluation of hemoglobin percent, liver and renal function tests, serum electrolytes, cholesterol, triglyceride, HBs antigen, HCV antibody and serum BNP levels, ECG, abdominal ultrasonography, and echocardiography. Results：There was a significant increase in the BNP level in cirrhotic patients compared to the other two groups (P＜0.05), and it was correlated with the severity of liver disease assigned as Child's classification (Liver function Child-Pugh classification, proposed in 1972) .There was a significant difference (P＜0.05). Also, there was a significant increase in the BNP level in cirrhotic patients with decompensation components compared to those without decompensation components (p = 0.000), history of hepatic encephalopathy, history of variceal bleeding, history of spontaneous bacterial peritonitis, presence of ascites and portal vein diameter > 11 mm in abdominal ultrasound (P＜0.05), and prolonged QTc interval in ECG. There was a significant increase in serum BNP in patients with cirrhosis with the following echocardiographic findings: IVST > 11 mm, PWT > 11 mm, LA diameter > 40 mm, EF% < 54%, and E/A ratio＜1 compared to those without these echocardiographic findings(P＜0.05). Conclusion：Compared with the control group, the BNP level increases in post hepatitis C cirrhotic patients and tends to