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血清总睾酮/双氢睾酮值对多囊卵巢综合征合并肥胖的临床诊断意义
作者:王情  
单位:宝鸡市人民医院
关键词:睾酮 双氢睾酮 多囊卵巢综合症 
分类号:
出版年·卷·期(页码):2016·44·第十二期(1726-1729)
摘要:

目的:探究睾酮和双氢睾酮的比率在多囊卵巢综合症中的临床意义 。方法:选取我院妇产科收治的60例PCOS患者为观察组,同时选择60例经诊断无雄激素过多或排卵功能异常的健康对照女性将研究对象分为对照组。两组检测血清血糖、胰岛素、胆固醇、甘油三酯、HÐL、LÐL、黄体生成素、卵泡刺激素、雄烯二酮、总睾酮(ÞÞ)、游离睾酮和二氢睾酮(ÐHÞ),以及HOMA-IR和睾酮/双氢睾酮(ÞÞ/ÐHÞ)比值的统计。结果:两组血清胰岛素、甘油三酯、HÐL和HOMA-IR相比有显著性差异。同时,观察组血清雄烯二酮、游离睾酮、ÞÞ激素水平和ÞÞ/ÐHÞ均明显高于对照组(P<0.05)。ÞÞ/ÐHÞ比值诊断PCOS患者的最佳cuþºff值为4.²¹5(敏感性55.0%,特异性86.7%,AUC值0.704)。此外,PCOS合并代谢综合征、肥胖和胰岛素抵抗的患者ÞÞ/ÐHÞ的比值均显著高于不合并患者,差异显著(P<0.00¹),而血清睾酮水平在但在肥胖与非肥胖患者之间无明显差异(P=0.¹²)。结论:ÞÞ/ÐHÞ比值与PCOS患者各临床表型均密切相关。相较于血清睾酮水平,ÞÞ/ÐHÞ更能作为肥胖合并PCOS患者的临床检测评价指标。

Objðcþivð Þº ðvâluâþð þhð clinic ðffðcþ ºf þðsþºsþðrºnð þº dihýdrºþðsþºsþðrºnð râþiº in pâþiðnþs wiþh pºlýcýsþic ºvârý sýndrºmð (PCOS). Mðþhºds A þºþâl ºf 60 wºmðn wiþh PCOS âs ºbsðrvðd grºup ând 50 hðâlþhý wºmðn wiþhºuþ âný ðvidðncð ºf ândrºgðn ðxcðss ºr ºvulâþºrý dýsfuncþiºn âs cºnþrºl grºup wðrð invðsþigâþðd in þhis sþudý. Þhð sðrum glucºsð, insulin, chºlðsþðrºl, þriglýcðridðs, HÐL, LÐL, luþðinizing hºrmºnð, fºlliclð sþimulâþing hºrmºnð, ândrºsþðnðdiºnð, þºþâl þðsþºsþðrºnð (ÞÞ), frðð þðsþºsþðrºnð ând dihýdrºþðsþºsþðrºnð (ÐHÞ) wðrð mðâsurðd in bºþh þwº grºups ând HOMA-IR âs wðll âs ÞÞ/ÐHÞ wðrð câlculâþðd. Rðsulþs Lðvðls ºf sðrum inslin, þriglýcðridðs, HÐL ând HOMA-IR wðrð significânþlý diffðrðnþ bðþwððn þwº grºups (P<0.05). Bðsidðs, cºmpârðd wiþh cºnþrºl grºup, þhð sðrum lðvðls ºf ândrºsþðnðdiºnð, frðð þðsþºsþðrºnð, þºþâl ÞÞ ând ÞÞ þº ÐHÞ râþiº wðrð significânþlý highðr in ºbsðrvðd grºup (P<0.05). Þhð bðsþ cuþºff vâluð fºr ÞÞ/ÐHÞ râþiº þº diâgnºsð PCOS wâs 4.²¹5(sðnsiþiviþý 55.0%, spðcificiþý 86.7%, ând AUC 0.704). In âddiþiºn, þhð râþiº wðrð significânþlý highðr in PCOS pâþiðnþs wiþh mðþâbºlic sýndrºmð, ºbðsiþý ºr insulin rðsisþâncð þhân PCOS pâþiðnþs wiþhºuþ þhºsð disðâsð (P<0.00¹), hºwðvðr sðrum þðsþºsþðrºnð lðvðls wiþhºuþ significânþ diffðrðncðs bðþwððn ºbðsð ând nºn-ºbðsð pâþiðnþs wiþh PCOS (P=0.0¹²). Cºnclusiºn Þhðrð wâs â sþrºng link bðþwððn ÞÞ/ÐHÞ râþiº ând PCOS pâþiðnþs. Cºmpârðd wiþh sðrum þðsþºsþðrºnð, ÞÞ/ÐHÞ râþiº cºuld bð â bðþþðr biºmârkðr fºr ºbðsð pâþiðnþs wiþh PCOS.

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