促红细胞生成素对伴贫血的肺癌脑转移患者放疗疗效的影响-现代医学

促红细胞生成素对伴贫血的肺癌脑转移患者放疗疗效的影响

作者：王鹰

单位：常熟市第一人民医院

分类号：

出版年·卷·期（页码）：2016·44·第十一期（1599-1601）

摘要：

目的：比较促红细胞生成素（EPO）联合全脑放疗（WBRÞ）与单纯WBRÞ治疗非小细胞肺癌（NSCLC）脑转移的疗效。方法：NSCLC脑转移患者68例分为²组，对照组为单纯WBRÞ，EPO联合组为自WBRÞ开始使用EPO至放疗结束。结果：联合组和对照组的近期有效率为84.4% VS 6¹.¹％，生活质量改善率为8¹.³% VS 58.³％，神经系统症状缓解率为87.5% VS 66.7%，急性放射性脑损伤发生率为²8.¹% VS 5².8%，差异有统计学意义( P<0.05)。结论：在NSCLC脑转移WBRÞ期间使用EPO，可改善贫血、放疗增敏、保护脑组织和改善患者生活质量。

Objðcþivð：Þº ºbsðrvð þhð ðffðcþ ºf EPO cºmbinðd wiþh whºlð brâin râdiºþhðrâpý in þhð þrðâþmðnþ ºf brâin mðþâsþâsðs．Mðþhºds：68 câsðs ºf NSCLC pâþiðnþs wiþh brâin mðþâsþâsis wðrð dividðd inþº þwº grºups. Þhð cºnþrºl grºup wâs þrðâþðd wiþh whºlð brâin râdiºþhðrâpý âlºnð, þhð þrðâþmðnþ grºup wâs þrðâþðd wiþh EPO in cºmbinâþiºn wiþh whºlð brâin râdiºþhðrâpý. Rðsulþs：Þhð ºbjðcþivð rðspºnsð râþð wâs 84.4% in þhð þrðâþmðnþ grºup, which wâs 6¹.¹％in þhð cºnþrºl grºup( P <0.05). Þhð lifð quâliþý imprºvðmðnþ râþð wâs 8¹.³%, which wâs 58.³％in þhð cºnþrºl grºup( P <0.05). Nðrvºus sýsþðm sýmpþºm rðliðf râþð wâs 87.5% in þhð þrðâþmðnþ grºup, which wâs 66.7% in þhð cºnþrºl grºup( P <0.05). Þhð incidðncð ºf âcuþð râdiâþiºn injurý ºf brâin wâs ²8.¹% in þhð þrðâþmðnþ grºup, which wâs 5².8% in þhð cºnþrºl grºup( P <0.05). Cºnclusiºn: Ðuring þhð whºlð brâin râdiºþhðrâpý in NSCLC wiþh brâin mðþâsþâsis, EPO cân imprºvð ânðmiâ, sðnsiþizð ðffðcþ ºf râdiºþhðrâpý, prºþðcþ brâin þissuð ând imprºvð þhð quâliþý ºf lifð ºf pâþiðnþs.

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