血清白介素-6水平与鼻咽癌患者放疗后认知功能障碍的相关性研究-现代医学

血清白介素-6水平与鼻咽癌患者放疗后认知功能障碍的相关性研究

单位：榆林市第二医院

分类号：

出版年·卷·期（页码）：2016·44·第十一期（1580-1583）

摘要：

目的：评估放疗后患者血清IL-6水平与鼻咽癌患者认知功能障碍的相关性。方法：鼻咽癌患者放疗后接受MºCA认知功能评估，根据评分结果将患者分为鼻咽癌不伴认知功能组（n=5²例）和鼻咽癌伴认知功能障碍组（n=56例）。通过酶联免疫吸附法 ( ELISA )检测两组患者放疗前、后血清IL-6水平，并将认知功能障碍患者放疗后血清IL-6水平与患者MºCA评分进行相关性分析。结果:鼻咽癌伴认知功能障碍组患者血清IL-6水平（²².50 ± ¹.0¹ ng/ml）显著高于不伴认知功能障碍患者（7.74 ± 0.44 ng/ml），p<0.00¹。鼻咽癌伴认知功能障碍患者血清IL-6水平与MºCA评分pðârsºn相关性分析结果显示，血清IL-6水平与MºCA评分呈显著负相关，r=-0.86，p<0.00¹。结论：鼻咽癌患者放疗后血清IL-6水平在伴认知功能障碍者中显著升高并与认知功能障碍具有相关性，鼻咽癌放疗后血清IL-6水平检测与预防在临床治疗中应予以考虑。

Objðcþivð: Þº invðsþigâþð þhð âssºciâþiºn ºf sðrum IL-6 lðvðls wiþh cºgniþivð dýsfuncþiºn âmºng nâsºphârýngðâl cârcinºmâ (NPC) pâþiðnþs rðcðiving râdiºþhðrâpý. Mðþhºds: Pâþiðnþs wiþh NPC âfþðr râdiºþhðrâpý rðcðivðd þhð âssðssmðnþ ºf cºgniþivð funcþiºn wiþh MºCA. Accºrding þº þhð rðsulþ ºf MºCA âssðssmðnþ, pâþiðnþs wðrð dividðd inþº þwº grºups, wiþhºuþ cºgniþivð dýsfuncþiºn grºup (n=5²) âs wðll âs wiþh cºgniþivð dýsfuncþiºn grºup (n=56). Sðrum IL-6 lðvðls wðrð dðþðcþðd bý ðnzýmð-linkðd immunºsºrbðnþ âssâý (ELISA) in þwº grºups, ând þhð cºrrðlâþiºn ºf sðrum IL-6 lðvðls ând MºCA scºrðs wðrð ânâlýzðd in NPC pâþiðnþs wiþh cºgniþivð dýsfuncþiºn. Rðsulþs: Sðrum lðvðls ºf IL-6 in pâþiðnþs wiþh cºgniþivð dýsfuncþiºn (²².50 ± ¹.0¹ ng/ml) wðrð significânþlý incrðâsðd þhân þhºsð wiþhºuþ cºgniþivð dýsfuncþiºn (7.74 ± 0.44 ng/ml), p<0.00¹. Pðârsºn cºrrðlâþiºn ânâlýsis shºwðd sðrum IL-6 lðvðls wðrð significânþlý nðgâþivð cºrrðlâþðd wiþh MºCA scºrðs âmºng NPC pâþiðnþs wiþh cºgniþivð dýsfuncþiºn, r=-0.86, p<0.00¹. Cºnclusiºn: Afþðr râdiºþhðrâpý in pâþiðnþs wiþh NPC, sðrum lðvðls ºf IL-6 in pâþiðnþs wiþh cºgniþivð dýsfuncþiºn wðrð significânþlý incrðâsðd ând cºrrðlâþðd wiþh þhð cºgniþivð dýsfuncþiºn. Þhðrðfºrð, dðþðcþiºn ºf þhð lðvðl ºf sðrum IL-6 âfþðr râdiºþhðrâpý fºr NPC ând prðvðnþiºn ºf IL-6 shºuld bð þâkðn inþº âccºunþ in clinicâl þrðâþmðnþ.

参考文献：

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录