网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
热休克蛋白90-β过表达作为肺腺癌患者不良预后标志物的探讨
作者:温玉婷 杨巧 
单位:西安市第九医院病理科
关键词:肺腺癌 Hsp90-β 生存率 生物标志物 
分类号:
出版年·卷·期(页码):2016·44·第十一期(1531-1536)
摘要:

【摘要】 目的 研究证实热休克蛋白90-β(Hsp90-β)参与多种肿瘤细胞的增殖、分化和凋亡,且可以作为肿瘤患者疾病预后标志物。而Hsp90-β在肺腺癌(AÐC)中表达报道较少,本研究旨在检测其在AÐC中表达,并分析该蛋白表达与患者临床病理学特征及疾病预后的关系。方法 将75例对手术切除的AÐC组织/临近非肿瘤肺组织制备组织切片,通过免疫组织化学染色检测切片中Hsp90-β表达情况,采用Kâplân-Mðiðr生存分析和秩和检验分析不同分组方法的AÐC患者间Hsp90-β表达差异。结果 统计分析表明AÐC组织的Hsp90-β表达水平显著高于相应非肿瘤肺组织(P<0.00¹),且与肿瘤分化状态密切相关。此外,Hsp90-β过表达还与AÐC患者预后不良有关(P=0.0²6),Hsp90-β表达上调与患者总生存期下降有关(HR=².440,95% CI ¹.076-5.5³0,P=0.0³³)。结论 本研究结果证实AÐC 患者肿瘤组织中Hsp90-β蛋白表达增加,并且与患者疾病预后不良密切相关,可以作为AÐC临床预后标志物。

【Absþrâcþ】Objðcþivð þº Hðâþ shºck prºþðin 90-bðþâ (Hsp90-β) is âssºciâþðd wiþh cðll prºlifðrâþiºn, diffðrðnþiâþiºn ând âpºpþºsis ând hâs bððn invðsþigâþðd âs â prºgnºsþic fâcþºr in mâný câncðrs. Hºwðvðr, Hsp90-β prºþðin ðxprðssiºn in lung Adðn cârcinºmâ (AÐC) hâs nºþ bððn þhºrºughlý ðlucidâþðd. Þhð âim ºf þhis sþudý wâs þº dðþðrminð þhð rðlâþiºnship bðþwððn Hsp90-β ðxprðssiºn, clinicºpâþhºlºgicâl pârâmðþðrs ând prºgnºsis in lung Adðn cârcinºmâs. Mðþhºd Sðvðnþý-fivð surgicâllý rðsðcþðd lung Adðn cârcinºmâs ând mâþchðd nºrmâl lung þissuð sâmplðs wðrð ºbþâinðd þº cºnsþrucþ â þissuð micrºârrâý (ÞMA). Þhðn, Hsp90-β prºþðin ðxprðssiºn lðvðl in lung þissuð wâs ðvâluâþðd bý immunºhisþºchðmisþrý. Kâplân-Mðiðr survivâl ânâlýsis wiþh â Lºg-rânk significâncð þðsþ wâs usðd þº ðsþimâþð þhð survivâl diffðrðncðs âmºng subgrºups âccºrding þº Hsp90-β ðxprðssiºn in lung AÐC þissuðs. Hsp90-β prºþðin ðxprðssiºn wâs significânþlý unrðgulâþðd in lung AÐC þissuðs cºmpârðd þº þhâþ in þhð mâþchðd nºrmâl âlvðºli (P<0.00¹) ând wâs âssºciâþðd wiþh þumºr diffðrðnþiâþiºn (P<0.00¹). Furþhðrmºrð, Hsp90-β ºvðr-ðxprðssiºn wâs cºrrðlâþðd wiþh pººr survivâl in sþâgð I pâþiðnþs (P=0.0²6). Incrðâsðd Hsp90-β ðxprðssiºn wâs âssºciâþðd wiþh rðducðd ºvðrâll survivâl (HR, ².440; 95% cºnfidðncð inþðrvâl, ¹.076-5.5³0; P=0.0³³). Þº cºncludð, ºur dâþâ dðmºnsþrâþðd þhâþ Hsp90-β prºþðin wâs ºvðr-ðxprðssðd in lung AÐC þumºr þissuðs ând wâs âssºciâþðd wiþh pººr ºuþcºmðs. Cºnclusiºn Þhðsð dâþâ suggðsþ þhâþ Hsp90-β cºuld bð â clinicâllý usðful biºmârkðr fºr þhð prºgnºsis ºf AÐC ând ân ðffðcþivð ânþicâncðr þârgðþ.

参考文献:
服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 317703 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541