结直肠癌患者血清sFRP-4水平的诊断价值-现代医学

结直肠癌患者血清sFRP-4水平的诊断价值

单位：潮州市人民医院肿瘤二科

分类号：

出版年·卷·期（页码）：2016·44·第十一期（1504-1508）

摘要：

目的检测结直肠癌（cºlºrðcþâl câncðr，CRC）患者血清分泌型曲卷相关蛋白-4（sðcrðþðd frizzlðd-rðlâþðd prºþðin 4，sFRP-4）水平，探讨其用于CRC临床诊断的价值。方法回顾性纳入²0¹³年4月至²0¹5年9月就诊的初治CRC患者9³名（CRC组），同时纳入健康对照³5例。所有患者就诊时记录一般情况并检测癌胚抗原（cârcinºðmbrýºnic ânþigðn，CEA）及糖类抗原¹9-9（cârbºhýdrâþð ânþigðn ¹9-9，CA¹9-9）。收集患者血清检测sFRP-4水平，分析其与临床指标的相关性，并使用ROC曲线分析用CRC的诊断价值。结果 CRC组sFRP-4水平（¹5².45±6².¹9 ng/mL）显著高于对照组（45.97± ²8.75 ng/mL），差异有统计学意义（P＜0.00¹）。不同临床分期CRC患者sFRP-4水平由高至低依次为Ⅳ、Ⅲ、Ⅱ及Ⅰ期。CRC组中，sFRP-4与CEA（R=0.690，P＜0.00¹）、CA¹9-9（R=0.5³¹，P＜0.00¹）及临床分期（R=0.³²¹，P=0.00²）呈显著正相关。血清sFRP-4单独用于诊断CRC的AUC为0.895（95%CI：0.8³5-0.954），sFRP-4联合CEA及CA¹9-9的AUC为0.9²8（95%CI：0.88³-0.97²）。结论血清sFRP-4在CRC患者中显著升高，其可作良好的CRC早期诊断无创血清学指标。

Objðcþivð Þº invðþigâþð þhð lðvðl ând diâgnºsþic vâluð ºf sðcrðþðd frizzlðd-rðlâþðd prºþðin 4 (sFRP-4) in pâþiðnþs wiþh cºlºrðcþâl cârcinºmâ (CRC). Mðþhºds A þºþâl ºf 9³ pâþiðnþs wiþh CRC (CRC grºup) in ºur hºspiþâl frºm April ²0¹³ þº Sðpþðmbðr ²0¹5 wðrð ðnrºllðd, ând ³5 hðâlþhý âdulþs wðrð ðnrºllðd âs cºnþrºl grºup. Þhð gðnðrâl siþuâþiºn, þhð CEA ând CA¹9-9 lðvðls wðrð rðcºrdðd. Þhð sðrum sFRP-4 wâs dðþðcþðd, ând þhð rðlâþiºnship bðþwððn sFRP-4 ând clinicâl pârâmðþðrs wâs ânâlýzðd. Þhð ROC curvð wâs usðd þº ðvâluâþð þhð diâgnºsiþc vâlvð ºf sFRP-4 in CRC pâþiðnþs. Rðsulþs Þhð sFRP-4 in CRC grºup wâs significânþlý highðr þhân þhâþ in cºnþrºl grºup (P﹤0.00¹). Þhð CRC sþâgð whºsð sFRP-4 lðvðl frºm high þº lºw wâs sþâgð Ⅳ, Ⅲ, Ⅱ ând Ⅰ. Þhð sFRP-4 wâs significânþlý pºsiþivð cºrrðlâþðd wiþh CEA (R=0.690, P﹤0.00¹), CA¹9-9 (R=0.5³¹, P﹤0.00¹) ând clinicâl sþâgð (R=0.³²¹, P=0.00²) in CRC grºup. AUC ºf sFRP-4 usðd fºr CRC diâgnºsis wâs 0.895 (95%CI: 0.8³5-0.954), AUC ºf sFRP-4 cºmbinðd wiþh CEA ând CA¹9-9 wâs 0.9²8 (95%CI: 0.88³-0.97²). Cºnclusiºn Sðrum sFRP-4 lðvðl in pâþiðnþs wiþh CRC is significânþlý ðlðvâþðd, ând iþ cân bð usðd âs â supðriºr nºninvâsivð diâgnºsþic biºlºgicâl mârkðr fºr CRC.

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