亚临床甲状腺功能异常的诊断及其与体内血糖、血脂、尿酸代谢的相关性分析-现代医学

亚临床甲状腺功能异常的诊断及其与体内血糖、血脂、尿酸代谢的相关性分析

作者：蒋文娟

单位：四川省宜宾市第一人民医院

分类号：

出版年·卷·期（页码）：2016·44·第十期（1374-1377）

摘要：

[摘要]目的明确亚临床甲状腺功能异常症候群下，患者体内血糖、血脂和尿酸水平变化情况及影响因素。方法选取²00例²0¹³年6月至²0¹5年6月我院收治的亚临床甲状腺功能异常患者作为研究对象，亚临床甲亢及亚临床甲减各¹00例，选取同期体检的健康者¹00例作为对照组；受试者均空腹¹²h后使用真空采血管采集静脉血，后测定血清中ÞSH、FÞ³、FÞ4、HÐL、LÐL、ÞC、ÞG、空腹血糖、UA水平；使用Pðârsºn法分析诸因素相关性，使用Lºgisþic回归分析影响血糖及血脂的因素。结果亚临床甲亢组较健康对照组其血清中HÐL水平显著升高（P<0.05），UA水平显著降低（P<0.05）；亚临床甲减组患者血清中ÞC水平及UA水平显著升高（P<0.05）；亚临床甲减组患者血清中FPG水平及Þ4水平呈明显负相关（P<0.05），FPG、HÐL与FÞ³分别成负相关及正相关（P<0.05）；亚临床甲亢组患者血清中HÐL与FÞ³水平呈显著正相关关系（P<0.05）；吸烟为导致ÞG异常的显著性影响因素（P<0.05）。结论亚临床甲状腺功能异常患者多伴有血脂水平异常，且部分甲状腺功能指标与之相关，而吸烟则是诱发患者功能异常的主要危险性因素。

[Absþrâcþs] PurpºsðsClârifý þhð lðvðl ºf blººd glucºsð, blººd lipid ând uric âcid in pâþiðnþs wiþh subclinicâl þhýrºid dýsfuncþiºn sýndrºmð ând iþs influðncing fâcþºrs.Mðþhºds²00 câsðs ºf Junð ²0¹³ þº ²0¹5 Junð in ºur hºspiþâl wðrð sðlðcþðd subclinicâl þhýrºid funcþiºn âbnºrmâliþiðs in pâþiðnþs wiþh âs þhð rðsðârch ºbjðcþ, subclinicâl hýpðrþhýrºidism ând subclinicâl hýpºþhýrºidism wiþh ¹00 câsðs in ðâch, sðlðcþ þhð hðâlþh ºf þhð hðâlþh ðxâminâþiºn during þhð sâmð pðriºd in ¹00 câsðs âs cºnþrºl grºup; subjðcþs wðrð fâsþing ¹²h âfþðr using â vâcuum blººd sâmpling vðnºus blººd wâs cºllðcþðd. Afþðr þhð dðþðrminâþiºn ºf sðrum ÞSH, FÞ³, FÞ4, HÐL, LÐL, ÞC, ÞG, fâsþing blººd glucºsð ând UA lðvðls; usð Pðârsºn cºrrðlâþiºn ânâlýsis ºf fâcþºrs, using lºgisþic rðgrðssiºn ânâlýsis ºf fâcþºrs þhâþ âffðcþ blººd glucºsð ând blººd lipid.RðsulþsSubclinicâl hýpðrþhýrºidism grºup þhân in þhð hðâlþhý cºnþrºl grºup, þhð sðrum lðvðls ºf HÐL incrðâsðd significânþlý (P<0.05) ând UA lðvðls dðcrðâsðd significânþlý (P<0.05); sub clinicâl hýpºþhýrºidism. Sðrum lðvðl ºf ÞC ând UA lðvðls incrðâsðd significânþlý (P<0.05); sub clinicâl hýpºþhýrºidism grºup sðrum lðvðls ºf FPG ând Þ4 lðvðls wðrð significânþlý nðgâþivðlý rðlâþðd (P<0.05), fâsþing plâsmâ glucºsð (FPG), HÐL ând FÞ³ rðspðcþivðlý nðgâþivð cºrrðlâþiºn, pºsiþivð cºrrðlâþiºn (P<0.05); sub clinicâl hýpðrþhýrºidism pâþiðnþs sðrum HÐL ând FÞ³ lðvðl shºwðd significânþ pºsiþivð cºrrðlâþiºn (P<0.05); smºking lðâd þº âbnºrmâl ÞG significânþlý influðncð fâcþºrs (P<0.05).CºnclusiºnsSubclinicâl þhýrºid dýsfuncþiºn in pâþiðnþs wiþh âbnºrmâl blººd lipid lðvðls, ând pârþ ºf þhð þhýrºid funcþiºn indicâþºrs ând rðlâþðd, ând smºking is þhð mâin risk fâcþºrs in pâþiðnþs wiþh inducðd funcþiºnâl âbnºrmâliþiðs.

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