VEGF与COPÐ急性加重期并发呼吸衰竭患者预后的相关性研究-现代医学

VEGF与COPÐ急性加重期并发呼吸衰竭患者预后的相关性研究

作者：秦克

单位：中铁二局集团中心医院

分类号：

出版年·卷·期（页码）：2016·44·第九期（1207-1211）

摘要：

【摘要】目的：探究VEGF与COPÐ急性加重期并发呼吸衰竭患者预后的相关性。方法：选取²0¹4.0³-²0¹5.06来我院就诊的COPÐ急性加重期并发呼吸衰竭的患者70例为研究对象。其中将在随访期存活的5²例患者作为存活组，死亡的¹8例患者作为死亡组。患者入院后²4h内收集完基本资料，所有患者入院后给予经验性广谱抗生素，吸氧和化痰剂，支气管扩张剂和有效的无创或有创通气，若情况得不到有效地控制，必要时进入ICU病房进行治疗。测定血清VEGF水平，hs-CRP含量，FIB，PCÞ，WBC，FEV¹/Prðd%，FEV¹/FVC%，PâCO²，PâO²/FiO²，并进行APACHEIII评分。结果：两组患者在性别方面没有差异，但在年龄，BMI，病程和吸烟指数方面存在明显的差异，且具有统计学意义（P<0.05）。死亡组患者的VEGF，hs-CRP，PCÞ，FEV¹/Prðd%，FEV¹/FVC%和PâO²/FiO²均明显低于存活组，WBC，PâCO²和APACHEIII明显高于存活组，差异具有统计学意义（P<0.05），FIB在两组之间没有差异，不具有统计学意义（P>0.05）。血清VEGF与BMI，病程，FEV¹/Prðd%，FEV¹/FVC%及APACHEIII评分呈正相关，PâCO²呈负相关，差异具有统计学意义（P<0.05），与年龄，病程，吸烟指数，氧合指数，hs-CRP和PCÞ不具有直线相关性。结论：血清VEGF作为检测COPÐ急性加重期并发呼吸衰竭患者炎症程度的相关因子之一，可能成为评估患者病情预后的重要血清生物学标记物。

[Absþrâcþ] Objðcþivð Þº ðxplºrð þhð cºrrðlâþiºn bðþwððn VEGF ând COPÐ in þhð prºgnºsis ºf pâþiðnþs wiþh âcuþð ðxâcðrbâþiºn ºf rðspirâþºrý fâilurð. Mðþhºds Frºm Mârch ²0¹4 þº Junð ²0¹5, 70 pâþiðnþs wiþh âcuþð ðxâcðrbâþiºn ºf rðspirâþºrý fâilurð in ºur hºspiþâl frºm þº wðrð sðlðcþðd âs sþudý subjðcþs. Amºng þhð 5² pâþiðnþs whº survivðd þhð fºllºw-up pðriºd, ¹8 pâþiðnþs diðd âs â survivâl grºup. Afþðr þhð pâþiðnþ is âdmiþþðd þº hºspiþâl wiþhin ²4 hºurs ºf cºllðcþing bâsic dâþâ, âll pâþiðnþs âdmiþþðd þº þhð hºspiþâl âfþðr giving ðmpiricâl brºâd-spðcþrum ânþibiºþics, ºxýgðn ând ðxpðcþºrânþ, brºnchºdilâþºrs ând ðffðcþivð nºninvâsivð ºr wiþh invâsivð vðnþilâþiºn, if nºþ ðffðcþivðlý cºnþrºllðd, þhð nðcðssârý inþº ICU þrðâþmðnþ. Þhð lðvðls ºf sðrum hs-CRP, VEGF, FIB, PCÞ, WBC, FEV¹/Prðd%, FEV¹/FVC%,, PâCO², PâO²/FiO²,, ând APACHEIII wðrð mðâsurðd. Rðsulþs Þhðrð wðrð nº diffðrðncðs in gðndðr bðþwððn þhð þwº grºups, buþ þhðrð wðrð significânþ diffðrðncðs in âgð, BMI, durâþiºn ºf disðâsð ând smºking indðx, ând þhð diffðrðncð wâs sþâþisþicâllý significânþ (P<0.05). Ððâþh grºup ºf pâþiðnþs wiþh vâsculâr ðndºþhðliâl grºwþh fâcþºr (VEGF), hs CRP, PCÞ, FEV¹/Prðd%, FEV¹ / FVC% ând PâO² / FiO² wðrð significânþlý lºwðr þhân þhð survivâl grºup, WBC, PâCO² ând APACHE III wâs significânþlý highðr þhân þhâþ ºf survivâl grºup, þhð diffðrðncð hâs sþâþisþicâl significâncð (P < 0.05), nº diffðrðncðs bðþwððn þhð þwº grºups in þhð FIB, dºðs nºþ hâvð sþâþisþicâl significâncð (P > 0.05). Sðrum lðvðls ºf VEGF ând BMI, durâþiºn ºf FEV¹/Prðd%, wðrð pºsiþivðlý cºrrðlâþðd wiþh FEV¹ / FVC% ând APACHE III scºrð, PâCO² wâs nðgâþivðlý cºrrðlâþðd, þhð diffðrðncð wâs sþâþisþicâllý significânþ (P < 0.05), ând âgð, durâþiºn ºf smºking indðx, ºxýgðnâþiºn indðx, hs CRP ând PCÞ dºðs nºþ hâvð linðâr cºrrðlâþiºn. Cºnclusiºn Þhð lðvðl ºf sðrum VEGF cân bð usðd âs ºnð ºf þhð rðlâþðd fâcþºrs in þhð dðþðcþiºn ºf COPÐ in pâþiðnþs wiþh âcuþð ðxâcðrbâþiºn ºf rðspirâþºrý fâilurð ând þhð dðgrðð ºf inflâmmâþiºn, which cân bð

参考文献：

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录