[Abstracts]Objective: To compare and observe abnormal condition and prognosis of fetal hemodynamics of 120 cases of patients with gestational diabetes by color Doppler ultrasonography. Methods: 120 cases of patients with gestational diabetes were treated with prenatal examination and hospital delivery ,who were selected as the observation group , 100 cases of pregnant women with normal pregnancy and in hospital delivery were selected as control group, the maximum blood flow velocity of and end diastolic blood flow velocity of umbilical artery, renal artery, middle cerebral artery hemodynamics indexes systolic stage and the ratio (S/D) and resistance index (RI) of end diastolic blood flow velocity of fetus of two groups were detected by color Doppler ultrasonography. Results: Umbilical artery, renal artery RI, S/D of patients of the observation group were higher than those of patients of the control group , the umbilical artery, renal artery, middle cerebral artery S/D, RI of patients of the control group measured x±2SD was as the normal range, growth restriction, fetal distress, neonatal asphyxia complication rate of Umbilical artery, renal artery abnormal fetus were higher than those of the umbilical artery, normal renal artery blood flow fetus , the incidence of fetal distress in the middle cerebral artery of abnormal arterial blood flow of fetus was higher than that of normal arterial blood flow fetus ,and the difference had statistical significance（P＜0.05）. Conclusion: Color Doppler ultrasonography in the detection of umbilical artery and renal artery hemodynamics, gestational diabetes combined with fetal growth restriction, fetal distress and neonatal asphyxia , S/D value and RI value of the umbilical artery, renal artery hemodynamics index can be significantly increased, and it can better predict perinatal prognosis.