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奥卡西平混悬液治疗儿童癫痫部分性发作的临床观察
作者:王鲁春 万俊 凌厉 
单位:江苏省无锡市人民医院
关键词:奥卡西平:卡马西平:儿童癫痫:部分性发作:脑电活动 
分类号:
出版年·卷·期(页码):2016··第八期(0-)
摘要:

[摘要] 目的:观察奥卡西平(Oxcarbazepine,OXC)混悬液单药治疗儿童癫痫部分性发作的临床效果及其对患儿脑电活动的影响。方法:选择2010年1月至2011年1月在我院接受治疗的部分性发作癫痫患儿80例,根据随机数字表法将所选病例分为两组,即观察组与对照组,每组各40例。观察组所有患儿采用奥卡西平(OXC)混悬液单药进行治疗,对照组所有患儿采用卡马西平(CBZ)进行治疗。观察并比较两组患儿在接受不同药物治疗后的临床效果及脑电活动情况。结果:在治疗后,观察组患儿脑电图显示θ波为(16.99±5.62),明显高于治疗前的(13.12±5.39);对照组患儿脑电图显示θ波为(18.61±6.29),明显高于治疗前的(13.09±5.21);而a波为(6.89±1.35),与治疗前相比有所降低;比较两组患者的临床疗效及脑电图活动情况,差异无统计学意义(P>0.05)。结论:对2至4岁患有部分性发作癫痫患儿来说,奥卡西平(OXC)与卡马西平(Carbamazepine ,CBZ)在治疗上的临床疗效相当,但奥卡西平(OXC)对患儿脑电背景活动的影响相对较小。

[ABSTRACT] Objective: To observe the effects of Oxcarbazepine suspension single drug on the treatment of partial seizure epilepsy in children and the influences on brain electrical activity. Methods: Eighty children with epilepsy seizures who were treated in our hospital from January 2010 to January 2011 were selected and randomly divided into the observation group and the control group, 40 cases in each group. The patients of the observation group were treated by Oxcarbazepine (OXC), while the patients of the control group were treated by carbamazepine (CBZ) . Then we observed and compared the clinical efficacy and EEG activity between two groups after treatment with different medicine. Results: In the observation group, the θ wave was (16.99 ± 5.62) after the treatment which was higher than before (13.12 ± 5.39). In the control group, the θ wave was (18.61 ± 6.29) after treatment which was higher than before (13.09 ± 5.21); the a wave was (6.89 ± 1.35) after treatment which was lower than before. The clinical effect and EEG of patients after treatment were compared between two groups, and there was no statistically significant difference (P > 0.05). Conclusion: OXC and CBZ have consistent effect on the treatment of children with a partial seizures at the age of 2-4 years old, but the OXC has less effect on EEG background activities.

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