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非小细胞肺癌患者肿瘤相关性贫血的特点
作者:孙婷婷 张晓晔 
单位:中国医科大学附属盛京医院
关键词:非小细胞肺癌 肿瘤相关性贫血 化疗 纠正贫血 
分类号:
出版年·卷·期(页码):2016··第八期(0-)
摘要:

目的:探讨NSCLC患者化疗前、化疗期间、化疗后复查期间肿瘤相关性贫血的特点。 方法:选取2014年1月~2015年12月,我科收治经病理学或组织学确诊的122例NSCLC患者,分别统计行4周期、6周期化疗患者化疗前、化疗期间及复查期间HbG值,及口服多糖铁复合物、叶酸和维生素B12联合治疗贫血患者的用药前后HbG值。采用SPSS19.0软件进行数据分析。结果:化疗开始前HbG值高于各周期化疗后HbG值;依次对前后两周期化疗后HbG值两两比较,仅4周期化疗患者中第1周期与第2周期(P=0.003)化疗后HbG值存在统计学差异,余均未见明显统计学差异(P均>0.05)。4周期化疗患者第1周期化疗前与末次化疗后ΔHbG值与6周期化疗患者相比无统计学差异(t=0.922,P=0.359)。4周期化疗患者中有5例、6周期化疗患者中有8例出现末次化疗后HbG值高于第1周期化疗前。3次复查HbG值,差异无统计学意义(F值分别为2.011,2.996;P值分别为0.136,0.053);化疗期间口服三联药物纠正贫血者7例,服药前后ΔHbG值与未用药患者比较存在统计学差异;化疗结束后服药者5例,其ΔHbG值与未用药患者比较无统计学差异。结论:化疗会导致NSCLC患者HbG值下降;4周期化疗与6周期化疗使患者HbG值下降程度相同;化疗期间及化疗结束后,HbG值处在基本稳定且偏低状态;口服多糖铁复合物、叶酸和维生素B12联合治疗可以改善患者化疗期间贫血状况,但不能改善患者化疗结束后贫血状况。

Objective To explore the characteristics of tumor related anemia in patients with NSCLC before and after chemotherapy. Methods Clinical data of 122 patients with NSCLC from January 2014 to December 2015 were collected.Statistical line 4 cycles, 6 cycles of chemotherapy before and during chemotherapy, and during the review period HbG value, HbG value of combined therapy of iron complex, folic acid and vitamin B12 in the treatment of anemia patients before and after treatment. Data analysis using SPSS19.0 software.Results Before the start of chemotherapy, the value of HbG was higher than that of HbG after chemotherapy. Comparison of HbG value two two after two cycles of chemotherapy before and after chemotherapy, there were statistically significant differences in HbG values between first cycles and second cycles (P=0.003) chemotherapy in patients with only 4 cycles of chemotherapy, there were no significant statistical differences (>0.05 mean P). 4 cycles of chemotherapy for patients with the first cycle of chemotherapy before and after the last chemotherapy and delta of HbG Chinese value compared with six cycles of chemotherapy in patients with no significant difference (t=0.922, P=0.359). There were 5 patients with 4 cycles of chemotherapy, 6 patients with cycles of chemotherapy and 8 patients with HbG were higher than first cycles before chemotherapy. 3 HbG values were reviewed, the difference was not statistically significant (F-measure was 2.011,2.996; P value was 0.136,0.053). During the chemotherapy of oral triple drug corrected 7 cases of anemia, before and after treatment HbG values compared with the untreated patients there is significant difference. 5 cases of chemotherapy after medication, the HbG values showed no significant difference compared with untreated patients. Conclusion Chemotherapy can lead to a decrease in HbG values in patients with NSCLC. 4 cycles of chemotherapy and 6 cycles of chemotherapy to patients with the same HbG value decreased. Du

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