Objective: To analyze the clinical application of Shikani optical stylet for early in severe trauma patients, and evaluate its effect. Methods: The clinical data of total 280 cases of patients with severe trauma from January 2008 to December 2014 in our hospital were analyzed, according to the difference of laryngoscope for early intubation, these patients were divided Macintosh group (132 cases) and Shikani group (148 cases). The levels of glottis exposure, the time for intubation and the rate of success for intubation were analyzed; the difference of hemodynamics and oxygen saturation (SpO2) were recorded; the incidence of lung infection, mortality and the complication for intubation were compared. Results: The levels of glottal exposure were compared in two groups and I, II grade was higher in S group than M group, and Ⅲ, Ⅳ grade was significantly less than M group (P<0.05); Compared with M group, the time of intubation was shorter and the rate of success was higher for intubation in S group (P<0.05); The mean arterial pressure (MAP), heart rate (HR) and SpO2 were compared in two groups before intubation and 5 min after intubation, the difference was not statistically significant (P>0.05), while compared with S group, the levels of MAP and HR were increased, and SpO2 were lower in M group in the process of intubation (P<0.05); Compared with M group, the complications of intubation including oral mucosal bleeding, sore throat and loose teeth were significantly lower in S group (P<0.05), and the incidence of pulmonary infection was significantly lower in S group (P<0.05), the mortality was slightly lower in S group than M group, but no significant difference (P>0.05). Conclusions: The Shikani laryngoscopes have many features including shorter time of intubation, higher success rate, the less effect of hemodynamics and less complications, and higher security in early endotracheal intubation with severe trauma patients, which was worthy of clinical use and promotio