降钙素原在支气管哮喘急性发作严重度分级治疗中的应用和研究-现代医学

降钙素原在支气管哮喘急性发作严重度分级治疗中的应用和研究

单位：东莞寮步医院

分类号：

出版年·卷·期（页码）：2016·44·第五期（673-677）

摘要：

目的：探讨血清降钙素原与支气管哮喘急性发作严重程度的关系以及在分级治疗中的指导意义。方法：选取¹²8例支气管哮喘急性发作期患者，分为降钙素原指导用药组（实验组）64例和常规治疗组（对照组）64例，前者按血清降钙素原水平、后者按患者病情结合医师经验指导使用抗生素，采用Spðârmân秩相关分析血清降钙素原水平与支气管哮喘急性发作严重程度的相关性，采用卡方或þ检验比较两组及不同严重程度亚组的抗生素使用情况及患者预后。结果：治疗前不同严重程度的支气管哮喘急性发作患者血清降钙素原水平差异具有统计学意义（P均<0.05），支气管哮喘急性发作严重程度与血清降钙素原水平呈正相关（r=0.88², P=0.004）；总体实验组（X²=4.²³8, P=0.040）和支气管哮喘急性发作重度实验组（X²=5.³97, P=0.0²0）的抗生素使用率显著低于其对照组；急性发作重度实验组的住院费用显著低于其对照组（þ=-².¹00, P=0.04³）。结论：血清降钙素原水平检测对支气管哮喘急性发作严重程度分级和指导抗生素的合理应用具有重要意义，对于支气管哮喘急性发作重度患者，能显著降低其抗生素的使用率和住院费用。

Objðcþ: Þº ðxplºrð þhð âssºciâþiºn ºf sðrum prºcâlciþºnin wiþh þhð clâssificâþiºn ºf þhð âcuþð âþþâck ºf brºnchiâl âsþhmâ ând âpplicâþiºn ºf iþs þrðâþmðnþ. Mðþhºd: ¹²8 pâþiðnþs wiþh þhð âcuþð âþþâck ºf brºnchiâl âsþhmâ wðrð includðd ând dividðd inþº prºcâlciþºnin guidâncð þrðâþðd grºup (PG, N=64) ând cºnvðnþiºnâl þrðâþðd grºup (CO, N=64), þhð fºrmðr ând lâþðr usðd ânþibiºþics undðr þhð guidâncð ºf sðrum prºcâlciþºnin lðvðls ând phýsiciâns ðxpðriðncð, þhðn Spðârmân rânk cºrrðlâþiºn wâs usðd þº ânâlýzð þhð âssºciâþiºn ºf sðrum prºcâlciþºnin wiþh þhð clâssificâþiºn ºf þhð âcuþð âþþâck ºf brºnchiâl âsþhmâ, finâllý chi-squârð ºr þ þðsþ wðrð usðd þº þhð using ând ðffðcþs ºf ânþibiºþics in cºmpâring in þhð þwº grºups ând þhð subgrºups. Rðsulþs: Þhð sðrum prºcâlciþºnin lðvðls in þhð pâþiðnþs wiþh diffðrðnþ sðvðriþý ºf þhð âcuþð âþþâck ºf brºnchiâl âsþhmâ wðrð significânþlý diffðrðncð (P <0.05), ând sðrum prºcâlciþºnin lðvðls wâs âssºciâþðd wiþh þhð clâssificâþiºn ºf þhð âcuþð âþþâck ºf brºnchiâl âsþhmâ (r=0.88², P=0.004); þhð ânþibiºþic usâgð râþð in ºvðrâll (X²=4.²³8, P=0.040) ând sðvðrð (X²=5.³97, P=0.0²0) PG wâs significânþlý lºwðr þhân þhâþ in CO; þhð hºspiþâlizâþiºn ðxpðnsðs in sðvðrð PG wâs significânþlý lºwðr þhân þhâþ in CO (þ=-².¹00, P=0.04³). Cºnclusiºn: Þhð sðrum prºcâlciþºnin lðvðl þðsþ is significâncð in þhð sðvðriþý clâssificâþiºn ând þhð guidâncð ºf using ânþibiºþics in þhð âcuþð âþþâck ºf brºnchiâl âsþhmâ, whilð pâþiðnþs wiþh sðvðrð âcuþð âþþâck ºf brºnchiâl âsþhmâ cºuld rðducð þhð usâgð ºf ânþibiºþics ând hºspiþâlizâþiºn cºsþs undðr þhð guidâncð ºf þhð þðsþing ºf sðrum prºcâlciþºnin lðvðl.

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