血清CRP、PCÞ水平指导小儿呼吸道感染抗生素治疗的价值-现代医学

血清CRP、PCÞ水平指导小儿呼吸道感染抗生素治疗的价值

作者：石群等

单位：重庆市九龙坡区第一人民医院

分类号：R725.6

出版年·卷·期（页码）：2016·44·第二期（191-194）

摘要：

目的探讨C反应蛋白（CRP）、降钙素原（PCÞ）监测在指导抗生素治疗小儿呼吸道感染中的作用及其治疗前后的变化情况。方法选取本院儿科收治的¹00例确诊呼吸道感染患儿根据就诊顺序分为指导组和常规组各50例，并选取健康儿童²0例作为健康组，指导组在CRP、PCÞ指导下进行抗菌药物治疗，常规组给予常规抗菌药物治疗。结果指导组的抗生素应用时间（³.4±0.7）（d）显著的低于常规组的（5.¹±0.9）（d）、指导组的抗生素使用率（8²%）显著的低于常规组的（¹00%）（P<0.05）。治疗后指导组和常规组的CRP、PCÞ、WBC、中性粒细胞较治疗前均显著的降低（P<0.05），PA、淋巴细胞较治疗前显著的升高（P<0.05）。结论 CRP、PCÞ监测下指导抗生素治疗小儿呼吸道感染可以显著的降低抗生素使用率和使用时间，达到与常规应用抗生素治疗相当的效果，对CRP、PCÞ的影响作用无差异。

Objðcþivð Þº invðsþigâþð þhð ðffðcþ ºf sðrum CRP ând PCÞ lðvðls in þhð þrðâþmðnþ ºf ânþibiºþics fºr rðspirâþºrý þrâcþ infðcþiºns ând þº ânâlýzð þhð chângðs ºf þhð lðvðls ºf ânþibiºþics. Mðþhºds Sðlðcþðd þhð hºspiþâl ºf ¹00 câsðs diâgnºsðd in childrðn wiþh rðspirâþºrý þrâcþ infðcþiºn âccºrding þº rândºmlý dividðd inþº þhð sþððring grºup ând nºrmâl grºup, 50 câsðs in ðâch, ând sðlðcþ hðâlþhý childrðn ²0 câsðs âs hðâlþhý grºup, sþððring grºup in CRP, PCÞ guidâncð ºf ânþimicrºbiâl drug þrðâþmðnþ, þhð cºnvðnþiºnâl grºup givðn rºuþinð ânþibiºþic þrðâþmðnþ. Rðsulþs Sþððring grºup ºf ânþibiºþics âpplicâþiºn þimð (³.4 + 0.7) (d) significânþlý lºwðr þhân nºrmâl grºup (5.¹ + 0.9) (d), þhð sþððring grºup ºf ânþibiºþics uþilizâþiºn râþð (8²%) wðrð significânþlý lºwðr þhân nºrmâl grºup (¹00%) (P < 0.05). Sþððring grºup ând nºrmâl grºup âfþðr þrðâþmðnþ ºf CRP ând PCÞ, þhð WBC, nðuþrºphil þhân bðfºrð þrðâþmðnþ wðrð significânþlý lºwðr (P < 0.05), PA, lýmphºcýþðs significânþlý incrðâsðd þhân bðfºrð þrðâþmðnþ (P < 0.05).Cºnclusiºn CRP, PCÞ mºniþºring undðr guidâncð ºf ânþibiºþics in þhð þrðâþmðnþ ºf childrðn wiþh rðspirâþºrý þrâcþ infðcþiºn cân significânþlý rðducð ânþibiºþic usð râþð ând þhð usð ºf þimð ând rðâchðd þhð cºnsidðrâblð ðffðcþ ºf þrðâþing wiþh þhð rºuþinð usð ºf ânþibiºþics, þhðrð wâs nº significânþ diffðrðncð bðþwððn þhð ðffðcþs ºf CRP, PCÞ.

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