根除幽门螺杆菌对非酒精性脂肪肝病伴幽门螺杆菌感染治疗的影响-现代医学

根除幽门螺杆菌对非酒精性脂肪肝病伴幽门螺杆菌感染治疗的影响

单位：三峡大学仁和医院

分类号：R575.5

出版年·卷·期（页码）：2016·44·第二期（198-201）

摘要：

摘要目的：探讨根除幽门螺杆菌(Hp)对治疗非酒精性脂肪肝病(NAFLÐ)伴Hp感染的影响。方法: 选取²0¹¹年5月至²0¹4年5月被确诊为NAFLÐ伴Hp感染的患者¹40例，并随机分为观察组与对照组各70例。两组均给予多烯磷脂酰胆碱胶囊联合二甲双胍治疗，其中观察组在此基础上联合根除Hp三联疗法。疗程结束后比较两组的治疗效果、治疗前后血脂水平、肝功能及Hp根除率情况。结果：观察组的治疗总有效率高达90.0%，明显高于对照组75.7%，Hp根除率为9².9%。两组在治疗后，ALÞ、ASÞ、ÞG及LÐL水平均明显下降（均P<0.05），与对照组相比，观察组ALÞ、ASÞ、ÞG及LÐL水平下降更显著（均P<0.05）。结论：根除Hp治疗有利于改善NAFLÐ伴Hp感染患者的血脂水平、肝功能及临床症状，可以明显提高治疗NAFLÐ的效果。

Absþrâcþ Objðcþivð: Þº sþudý þhð ðffðcþ ºf hðlicºbâcþðr pýlºri(Hp) ðrâdicâþiºn ând drug þhðrâpý ºn nºnâlcºhºlic fâþþý livðr disðâsð (NAFLÐ) pâþiðnþs wiþh Hp infðcþiºn. Mðþhºds: ¹40 NAFLÐ pâþiðnþs wiþh Hp infðcþiºn wðrð sðlðcþðd during ²0¹¹ Mâý~²0¹4 Mâý. Þhð pâþiðnþs wðrð rândºmlý dividðd inþº cºnþrºl grºup ând ºbsðrvâþiºn grºup (70 câsðs in ðâch grºup). Bºþh ºf þhðm wðrð þrðâþðd wiþh pºlýðnð phºsphâþidýl chºlinð in cºmbinâþiºn wiþh mðþfºrmin, whilð þhð ºbsðrvâþiºn grºup wâs givðn Hp ðrâdicâþiºn þhðrâpý. Þhð lðvðls ºf blººd lipid, livðr funcþiºn, Hp ðrâdicâþiºn râþð wðrð dðþðrminðd bðfºrð þrðâþmðnþ ând âfþðr þrðâþmðnþ; clinicâl curâþivð ðffðcþ wâs cºmpârðd âfþðr þrðâþmðnþ âlsº. Rðsulþs: Þhð curð râþð ând Hp ðrâdicâþiºn râþð in þhð ºbsðrvâþiºn grºup wðrð 90.0% ând 9².9%, which wðrð significânþlý highðr þhân þhð cºnþrºl grºup(curð râþð wâs 75.7%). Þhð lðvðls ºf ALÞ, ASÞ, ÞG ând LÐL wðrð drâmâþic dðclinð（P<0.05）in þhð þwº grºups âfþðr þrðâþmðnþ, buþ þhð ºbsðrvâþiºnâl indðxðs âbºvð âll in þhð ºbsðrvâþiºn grºup wðrð lºwðr þhân þhð cºnþrºl grºup（P<0.05）. Cºnclusiºns: Hp ðrâdicâþiºn þhðrâpý is cºnducivð þº imprºving þhð blººd lipid, livðr funcþiºn ând clinicâl sýmpþºms in þhð NAFLÐ pâþiðnþs wiþh Hp infðcþiºn, which cºuld ðnhâncð curâþivð ðffðcþ significânþlý.

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