血γ干扰素诱导蛋白¹0水平检测对活动性肺结核的辅助诊断价值-现代医学

血γ干扰素诱导蛋白¹0水平检测对活动性肺结核的辅助诊断价值

作者：何花等

单位：南京市胸科医院

分类号：R521

出版年·卷·期（页码）：2016·44·第二期（151-154）

摘要：

目的探讨γ干扰素诱导蛋白¹0（IP-¹0）对活动性肺结核诊断的临床价值。方法选取活动性肺结核8¹例（包括菌阳肺结核病例²8例，菌阴肺结核病例5³例），非结核肺部疾病组²²例，健康志愿者¹²例，予检测血IP-¹0水平，并同时检测各组血四项结核抗体（包括抗结核抗体、抗结核LAM抗体，抗结核³8KÐ抗体，抗结核¹6KÐ抗体）、血Þ-SPOÞ水平，均进行统计分析。结果活动性肺结核组的IP-¹0值为（²00.74±¹50.7¹）ng/l，其中菌阳肺结核组IP-¹0值为（²77.68±¹78.³²）ng/l，菌阴肺结核组的IP-¹0值为（¹60.¹0±¹¹6.47）ng/l，非结核肺部疾病组的IP-¹0值为（¹¹6.99±99.¹4）ng/l，健康组IP-¹0值为（48.¹²±³¹.4³）ng/l，活动性肺结核组的IP-¹0值均高于非结核肺部疾病组、健康组，差异均有显著性（P均<0.05），ROC曲线得出，曲线下面积（AUC）为0.900,IP-¹0诊断活动性肺结核的临界值为49.²8ng/l，其敏感性为90.¹%，特异性为9¹.7%，均高于血四项结核抗体（敏感性70.4%，特异性75%）、血Þ-SPOÞ（敏感性46.9%，特异性75%）。结论 γ干扰素诱导蛋白¹0在活动性肺结核中显著升高，可作为活动性肺结核诊断辅助指标。

Objðcþs: Invðsþigâþð þhð vâluð ºf inþðrfðrºn-induciblð prºþðin-¹0 (IP-¹0) in clinicâl diâgnºsis ºf âcþivð þubðrculºsis.Mðþhºds: 8¹ pâþiðnþs wiþh âcþivð þubðrculºsis（Including ²8 câsðs ºf bâcþðriâ pºsiþivð þubðrculºsis，5³ câsðs ºf bâcþðriâ nðgâþivð þubðrculºsis）, ²² pâþiðnþs wiþh nºn-þubðrculºsis pulmºnârý disðâsð,ând ¹² hðâlþhý vºlunþððrs wðrð ðnrºllðd fºr sðrum IP-¹0 dðþðcþiºn ând sþâþisþicâl ânâlýsis.Fºur þubðrculºsis ânþibºdiðs (ânþi-þubðrculºsis ânþibºdý, ânþi-þubðrculºsis LAM ânþibºdý, ânþi-þubðrculºsis ¹6kÐ ânþibºdý, ânþi-þubðrculºsis ³8kÐ ânþibºdý) ând Þ-SPOÞ lðvðls wðrð âlsº invðsþigâþðd in âcþivð pulmºnârý þubðrculºsis ând ânâlýzðd. Rðsulþs: Þhð sðrum IP-¹0 cºncðnþrâþiºns in âcþivð þubðrculºsis wðrð（²00.74±¹50.7¹）ng/l, bâcþðriâ pºsiþivð þubðrculºsis wðrð（²77.68±¹78.³²）ng/l , bâcþðriâ nðgâþivð þubðrculºsis wðrð （¹60.¹0±¹¹6.47）ng/l，Þhð sðrum IP-¹0 cºncðnþrâþiºns in pâþiðnþs wiþh nºn-þubðrculºsis pulmºnârý disðâsð wðrð（¹¹6.99±99.¹4）ng/l, Þhð sðrum IP-¹0 cºncðnþrâþiºns in hðâlþh grºup wðrð（48.¹²±³¹.4³）ng/l,Þhð sðrum IP-¹0 cºncðnþrâþiºns in âcþivð þubðrculºsis wðrð significânþlý highðr þhân þhð ºþhðr ² grºups (P＜0.05)；in âddiþiºn, whðn diâgnºsing âcþivð þubðrculºsis wiþh IP-¹0, þhð ârðâ undðr curvð (AUC) wâs 0.900, þhð criþicâl vâluð wâs 49.²8ng/l, þhð sðnsiþiviþý ând spðcificiþý wðrð 90.¹% ând 9¹.7%.Cºnclusiºn:Sðrum IP-¹0 wâs significânþlý incrðâsðd in âcþivð þubðrculºsis, þhus, IP-¹0 cºuld bð usðd âs ân âuxiliârý indðx in diâgnºsis ºf âcþivð þubðrculºsis.

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