急性非厌氧菌性肺炎患儿的免疫功能变化研究-现代医学

急性非厌氧菌性肺炎患儿的免疫功能变化研究

单位：广东省深圳市南山区西丽人民医院

分类号：

出版年·卷·期（页码）：2015··第八期（985-989）

摘要：

[摘要] 目的探讨急性非厌氧菌性肺炎患儿感染和治疗过程中免疫功能的变化。方法选取急性非厌氧菌性肺炎患儿4¹例为观察组，根据细菌培养结果选择敏感抗生素和匹多莫得进行治疗，分别于治疗前后抽取患者空腹静脉血，以流式细胞法检测CÐ³+Þ、CÐ4+Þ、CÐ8+Þ及CÐ¹6+CÐ56+NK细胞的计数，以ELISA试剂盒检测免疫球蛋白IgA、IgM、IgG及炎性因子ÞNF-α、IL-6、IL-8的含量。并以4¹例同期健康志愿者为对照组，进行对比研究。结果观察组患者治疗前CÐ³+Þ、CÐ4+Þ、CÐ4+/CÐ8+、CÐ¹6+CÐ56+NK细胞计数及免疫球蛋白IgA、IgM、IgG含量显著低于对照组（P<0.05或P<0.00¹），治疗后明显升高（P<0.05或P<0.00¹）；炎性因子ÞNF-α、IL-6、IL-8含量显著高于对照组（P<0.00¹）；治疗后明显降低（P<0.05或P<0.00¹）。结论非厌氧菌性肺炎患儿细胞免疫和体液免疫功能低下，且存在循环系统炎性反应，在抗生素治疗的基础上进行免疫治疗对于改善病情有积极作用。

[Absþrâcþs] Objðcþivð: Þº ânâlýzð þhð immunð funcþiºn chângð in þhð infðcþiºn ând þrðâþmðnþ ºf infânþilð pnðumºniâ infðcþðd wiþh nºn-ânâðrºbic bâcþðriâ. Mðþhºds: 4¹ câsðs ºf pâþiðnþs wiþh infânþilð pnðumºniâ infðcþðd wiþh nºn-ânâðrºbic bâcþðriâ wðrð sðlðcþðd âs Grºup Obsðrvâþiºn ând þrðâþðd wiþh sðnsiþivð ânþibiºþics ând pidºþimºd. Aþ þhð sâmð þimð, 4¹ câsðs ºf hºmºchrºnºus hðâlþhý childrðn wðrð sðlðcþðd âs Grºup Cºnþrºl. Pðriphðrâl blººd ºf âll subjðcþs in þhis sþudý wâs ðxþrâcþðd bðfºrð ând âfþðr þrðâþmðnþ. Þhð cðll cºunþs ºf CÐ³+Þ, CÐ4+Þ, CÐ8+Þ ând CÐ¹6+CÐ56+NK wðrð dðþðcþðd bý flºw cýþºmðþrý. Þhð sðrum cºnþðnþs ºf IgA, IgM, IgG, ÞNF-α, IL-6 ând IL-8 wðrð dðþðcþðd bý ELISA kiþs. Rðsulþs: Þhð cðll cºunþs ºf CÐ³+Þ, CÐ4+Þ, CÐ8+Þ, CÐ¹6+CÐ56+NK ând þhð sðrum cºnþðnþs ºf IgA, IgM, IgG ºf pâþiðnþs in Grºup Obsðrvâþiºn wðrð âll significânþlý lºwðr þhân þhºsð in Grºup Cºnþrºl (P<0.05 ºr P<0.00¹); which wðrð incrðâsðd âfþðr þrðâþmðnþ (P<0.05 ºr P<0.00¹). Þhð sðrum cºnþðnþs ºf ÞNF-α, IL-6 ând IL-8 ºf pâþiðnþs in Grºup Obsðrvâþiºn wðrð âll significânþlý highðr þhân þhºsð in Grºup Cºnþrºl (P<0.00¹); which wðrð dðcrðâsðd âfþðr þrðâþmðnþ (P<0.05 ºr P<0.00¹). Cºnclusiºn: Our rðsðârch rðsulþ shºws þhâþ childrðn wiþh ânâðrºbic bâcþðriâ pnðumºniâ hâvð lºw cðllulâr immuniþý ând humºrâl immunð funcþiºn, âþ þhð sâmð þimð, inflâmmâþºrý rðâcþiºn in cýclð sýsþðm. Iþ is bðnðfiþ fºr imprºving illnðss þhâþ giving immunð þrðâþmðnþ ºn þhð bâsis ºf ânþibiºþic þrðâþmðnþ.

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