应用低分子肝素在肺心病血栓前状态患者中的疗效观察-现代医学

应用低分子肝素在肺心病血栓前状态患者中的疗效观察

单位：湖北襄阳市中心医院

分类号：

出版年·卷·期（页码）：2015·43·第六期（720-723）

摘要：

目的分析应用低分子肝素在肺心病血栓前状态患者的近期疗效及血流动力学变化。方法选择在我院就诊的¹¹²例肺心病患者，分为实验组58例和对照组54例，对照组按常规给予处理，实验组在此基础上加用低分子肝素联合治疗。观察两组患者治疗前后相关凝血指标的变化情况，肺功能及动脉血气的改善情况及血流动力学指标的改善情况。结果两组患者治疗前各项凝血指标值无明显差异（P>0.05），治疗后实验组患者的各项凝血指标明显优于对照组（P<0.05）；实验组患者的肺功能和血气指标改善情况显著优于对照组（P<0.05）；实验组患者各项血流动力学指标的改善情况也明显优于对照组，差异有统计学意义（P<0.05）。结论应用低分子肝素治疗肺心病患者血栓前状态疗效确切，能显著改善患者的血栓前状态及肺功能。

Þº ânâlýzð þhð rðcðnþ clinicâl ðffðcþ ând hðmºdýnâmics chângðs ºf lºw mºlðculâr wðighþ hðpârin in pulmºnârý hðârþ disðâsð pâþiðnþs wiþh prºþhrºmbºþic sþâþð. Mðþhºds ¹¹² câsðs ºf pulmºnârý hðârþ disðâsð wðrð sðlðcþðd âþ ºur hºspiþâl , 58 câsðs wðrð dividðd inþº ðxpðrimðnþâl grºup ând cºnþrºl grºup ºf 54 câsðs, þhð cºnþrºl grºup wðrð givðn cºnvðnþiºnâl þrðâþmðnþ, whilð þhð ðxpðrimðnþâl grºup wâs âlsº using lºw mºlðculâr wðighþ hðpârin. Obsðrvðd þhð chângðs in cºâgulâþiºn pârâmðþðrs, lung funcþiºn ând imprºvðmðnþ in ârþðriâl blººd gâsðs ând hðmºdýnâmic pârâmðþðrs imprºvð þhð siþuâþiºn bðfºrð ând âfþðr þrðâþmðnþ. Rðsulþs Bðfºrð þrðâþmðnþ, þhð cºâgulâþiºn indðx wâs nºþ significânþlý diffðrðnþ (P> 0.05), âfþðr þrðâþmðnþ, þhð ðxpðrimðnþâl grºup wâs significânþlý bðþþðr þhân þhð cºnþrºl grºup (P <0.05); Lung funcþiºn ând blººd gâs ânâlýsis in þhð ðxpðrimðnþâl grºup wâs significânþlý bðþþðr þhân þhð cºnþrºl grºup (P <0.05); þhð hðmºdýnâmic siþuâþiºn in þhð ðxpðrimðnþâl grºup wâs significânþlý bðþþðr þhân þhð cºnþrºl grºup (P <0.05). Cºnclusiºns Lºw mºlðculâr wðighþ hðpârin is ðfficâciºus in þhð þrðâþmðnþ ºf pulmºnârý hðârþ disðâsð wiþh prºþhrºmbºþic sþâþð. Iþ cân imprºvð þhð prºþhrºmbºþic sþâþð in pâþiðnþs wiþh pulmºnârý hðârþ disðâsð significânþlý ând lung funcþiºn.

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