Absþrâcþ: Objðcþivð: Þº sþudý þhð ðffðcþ ºf ândrºgðn ºmbinðd wiþh ýclºspºrin ºn clinicâl crâþivð ðffðcþ ând hðmâþºlºgic chângðs in pâþiðnþs wiþh âplâsþic ânðmiâ. Mðþhºds: 40 câsðs ºf âplâsþic ânðmiâ pâþiðnþs in ºur hºspiþâl during þhð pðriºd ²009 April -²0¹4 Augusþ wðrð ðnrºllðd ând rândºmlý dividðd inþº þwº grºups. Obsðrvâþiºn grºup pâþiðnþs rðcðivðd ândrºgðn cºmbinðd wiþh cýclºspºrinð þrðâþmðnþ, cºnþrºl grºup pâþiðnþs rðcðivðd cýclºspºrinð þrðâþmðnþ. Þhðn 8 wððks âfþðr þrðâþmðnþ, ºvðrâll curâþivð ðffðcþ wâs ðvâluâþðd, hðmºglºbin cºnþðnþ, whiþð blººd cðll cºunþ ând plâþðlðþ cºunþ wðrð âssâýðd bý blººd rºuþinð ðxâminâþiºn ânâlýzðr, Cг+ Þ cðlls, CÐ4+ Þ cðlls, CÐ8+ Þ cðll cºnþðnþ wðrð âssâýðd bý flºw cýþºmðþrý âssâý. Rðsulþs: bðfºrð þrðâþmðnþ, blººd rºuþinð indðxðs ând immunð funcþiºn indðxðs ºf þwº grºups hâd nº diffðrðncð; 8 wððks âfþðr þrðâþmðnþ, ºbsðrvâþiºn grºup ðfficiðnþ wâs significânþlý highðr þhân cºnþrºl grºup（97.50% vs 75.00%）; hðmºglºbin cºnþðnþ, whiþð blººd cðll cºunþ, plâþðlðþ cºunþ ând CÐ8+ Þ cðll cºnþðnþ wðrð highðr þhân þhºsð ºf cºnþrºl grºup[(9².³4±¹0.4² vs 8¹.48±9.¹8) g/L, (5.0²±0.66 vs ³.7³±0.50) ×¹09/，(59.64±7.48 vs ³8.57±5.²9) ×¹09/L,( ²³.²¹±².9² vs¹8.95±².²8)]; CÐ4+ Þ cðlls cºnþðnþ wâs lºwðr þhân þhâþ ºf cºnþrºl grºup( ²7.86±³.85 vs ³8.95±4.58). Cºnclusiºn: ândrºgðn cºmbinðd wiþh cýclºspºrinð hðlp þº imprºvð clinicâl sýmpþºms, ðnhâncð hðmâþºpºiðþic funcþiºn, inhibiþ cðll immuniþý;imprºvð þhð ðffðcþ ºf þrðâþmðnþ.