高迁移率族蛋白B1与子痫前期的相关性的研究-现代医学

高迁移率族蛋白B1与子痫前期的相关性的研究

单位：无锡市妇幼保健院

分类号：

出版年·卷·期（页码）：2015·43·第三期（349-351）

摘要：

目的：探讨高迁移率族蛋白B1（HMGB1）及其受体晚期糖基化终末产物（RAGE）与子痫前期发病的相关性。方法：用ELISA检测轻度子痫前期（A组，34例），重度子痫前期（B组，30）和正常妊娠（C组，30例）孕妇妊娠晚期血清HMGB1和RAGE水平。结果：A组和B组血清HMGB1、RAGE水平高于C组，分别比较差异均有统计学意义（P<0.01），A组与B组比较，差异有统计学意义（P<0.05）。结论：子痫前期孕妇血清HMGB1及RAGE水平增高，并且与子痫前期严重程度有关。

Objective To investigate the correlation of the expressions of high mobility group box 1 (HMGB1) and receptor for advanced glycation end products(RAGE) in maternal serum with preeclampsia. Methods Serum HMGB1 and RAGE were detected using ELISA in 34 preeclampasia pregnant women (group A), 30 preeclampasia pregnant women (group B) and 30 pregnat women without preeclampsia (group C). Results The serum concentrations of HMGB1 and RAGE in group A and group B were significantly higher than that in group C（P<0.01）.There was signficant difference between group A and group B（P<0.05）. Conclusions The increased expression of HMGB1 and RAGE in preeclampsia, which is related with the progress of the disease.

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