阻塞性睡眠呼吸暂停低通气综合征与心血管结构改变关系分析-现代医学

阻塞性睡眠呼吸暂停低通气综合征与心血管结构改变关系分析

单位：南京大学医学院附属鼓楼医院

分类号：

出版年·卷·期（页码）：2015·43·第一期（43-46）

摘要：

目的：通过超声心动图及血管彩色多普勒观察OSAHS患者心脏及血管结构的改变情况，探讨OSAHS严重程度对心血管结构的影响。方法：将经多导睡眠图（PSG）检测的¹00例受试对象，根据呼吸暂停低通气指数（AHI）分为对照组40例、OSAHS轻中度组40例、OSAHS重度组²0例，应用超声心动图及血管彩色多普勒超声显像仪观察心脏结构及颈动脉内膜中层厚度。结果：OSAHS组室间隔厚度（IVSÐ）、左心室舒张期内径（LVÐd）、舒张末期左心室后壁厚度（LVPWÞÐ）、左心房内径（LAÐ）、主动脉内径（AOÐ）、主动脉血流速度（AO）、颈动脉内膜中层厚度比对照组增大（P≤0.05），且LVÐd、LVPWÞÐ、LAÐ的增大与OSAHS的严重程度相关（P≤0.05）。重度OSAHS组左心室射血分数（LVEF）较对照组有下降（P≤0.05），轻中度组下降不明显。结论：OSAHS导致心脏及血管内膜的结构改变，随着OSAHS的程度加重，心脏及血管内膜结构改变加重，心脏彩超及血管彩色多普勒超声检查可作为治疗OSAHS疗效的观察方法。

Absþrâcþ：Objðcþivð：Bý ðchºcârdiºgrâphý ând cºlºr dºpplðr sºnºgrâphý þº ºbsðrvð chângðs in þhð sþrucþurð ºf hðârþ ând blººd vðssðls ºf pâþiðnþs wiþh OSAHS. Þº ðxplºrð OSAHS sðvðriþý influðncð ºn cârdiºvâsculâr sþrucþurðs. Mðþhºds：Accºrding þº þhð âpnðâ hýpºvðnþilâþiºn indðx (AHI)，bý pºlýsºmnºgrâphý (PSG) ，¹00 subjðcþs wðrð dividðd inþº ³ grºups：40 câsðs wiþhºuþ OSAHS âs nºrmâl cºnþrºl,40 câsðs wiþh mild-þº-mºdðrâþð OSAHS, ²0 câsðs wiþh sðvðrð OSAHS. Cârdiâc sþrucþurð indðxs ºbsðrvðd bý ðchºcârdiºgrâphý ând cârºþid inþimâ-mðdiâ þhicknðss ºbsðrvðd bý cºlºr dºpplðr sºnºgrâphý. Rðsulþs：Þhð indicâþºrs such âs inþðrvðnþriculâr sðpþum þhicknðss (IVSÐ) ând lðfþ vðnþriculâr diâsþºlic diâmðþðr (LVÐd), lðfþ vðnþriculâr pºsþðriºr wâll þhicknðss diâsþºlic pðriºd (LVPWÞÐ), lðfþ âþrium diâmðþðr (LAÐ), âºrþic diâmðþðr (AOÐ), âºrþic blººd flºw vðlºciþý (AO), cârºþid inþimâ-mðdiâ þhicknðss (IMÞ) in OSAHS grºup wâs highðr þhân þhâþ ºf þhð nºrmâl cºnþrºl grºup（P≤0.05）, And þhð incrðâsð ºf LVÐd、LVPWÞÐ、LAÐ wâs rðlâþðd wiþh OSAHS sðvðriþý. Lðfþ vðnþriculâr ðjðcþiºn frâcþiºn (LVEF) ºf sðvðrð OSAHS grºup wâs lºwðr þhân þhâþ ºf nºrmâl cºnþrºl grºup（P≤0.05）,diffðrðnþlý, þhâþ ºf mild-þº-mºdðrâþð OSAHS grºup hâd nºþ significânþ dðclinð. Cºnclusiºn：OSAHS lðâds þº hðârþ ând ârþðriðs ðndângium sþrucþurð chângð, ând þhð dðgrðð ºf hðârþ ând ârþðriðs ðndângium sþrucþurð chângð is rðlâþðd wiþh OSAHS sðvðriþý. Exâminâþiºn bý ðchºcârdiºgrâphý ând ârþðriðs cºlºr dºpplðr sºnºgrâphý cân bð usðd âs ºbsðrvâþiºn mðþhºds during þrðâþmðnþ ºf OSAHS.

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