Objective: To study the term effect of tirofiban and thrombus aspiration on emergency percutaneous coronary intervention(PCI) patients with acute ST-segment elevation myocardial infarction(STEMI). Methods: Sixty-eight patients with STEMI received emergency PCI were selected. All the infarct-related coronary artery(IRA) were sub-total or total occlusion and rich in thrombus. Thirty-seven patients received tirofiban and thrombus aspiration(Thrombus Aspiration Group). Other thirty-one patients received routine PCI (Conventional PCI Group).TIMI3 blood flow, no reflow or slow flow incidence of IRA after PCI, intraoperative and postoperative complications and major cardiac adverse event(MACE) in the 30th days of the two groups were compared. Results: Compared with the conventional PCI group, intraoperative and postoperative complications(such as reperfusion arrhythmias, bleeding, hematoma, etc.) in the thrombus aspiration group didn’t reduce(P>0.05). But the thrombus-aspiration group had a significantly higher rate of IRA TIMI3 blood flow, lower rate of no-reflow or slow-flow and lower rate of using balloon(P˂0.05). In addition, MACE occurrence in thrombus-aspiration group was lower partly than conventional PCI group in the 30th days(P˂0.05). Conclusion: Tirofiban and thrombus aspiration can improve IRA bloodstream and reduce no-reflow/slow-flow phenomenon in STEMI patients after emergency PCI, also can decrease MACE occurrence in the 30th days and significantly improve the prognosis of patients with STEMI. |