Abstract Objective:To investigate the histological features, clinical manifestation, differential diagnosis,treatment options and prognosis of penis carcinosarcoma. Methods:The clinical, pathological and follow up data of 1 case of Penis Carcinosarcoma was reviewed, And the related articles of carcinosarcoma and sarcomatiod carcimoma were reviewed as a whole. Results:The post-operative histopathology of penis carcinosarcoma showed the tumor with epithelial and sarcomatoid mesenchymal components. The immumohistochemical test of the case was positive for CK5/6, P63, CK, CK8/18 and negative for Vimentin in epithelial cancer area, but positive for Vimentin in sarcomatoid area, and Ki-67 was about 40%, The final diagnosis was penis carcinosarcoma . There was no further treatment for post-operation. Conclusion:Penis carcinosarcoma have the biological behavior of invasive growth. They are often in an advance stage at first diagnosis, leading to an unfavorable prognosis. The final diagnosis depends on histopathology and immumohistochemical test, the first choice of treatment is operation . |