Objective: To investigate the effect of remifentanil in patient controlled intravenous analgesia (PCIA) on maternity , foetus and neonatal in labour by comparing with epidural analgesia and spontaneous labor. Methods: 60 full-term pregnant women were randomized to three groups at. Group A received PCIA with remifentanil by electronic pump. There was 0.05μg﹒kg-1﹒min-1 background dose and 2 min lock-out time while uterus constrictions coming until cervix completely opened. Group B received epidural analgesia with ropivacaine and remifentanil.There was 5ml loading dose,6ml﹒h-1 background infusion and 15 min lock-out time. Group C didn′t use medicine to ease the pain adverse effect Visual analogue score(VAS), birth process, volume of hemorrhage, the Apgar score, blood gas analysis of foetal umbilical artery, milk secretion, neonatal nerval and adaptive capacity score（NACS）, adverse effect were recorded. Results: Along with progress of birth process, VAS was obviously higher in group A than that of group B(P<0.05).Active stage was obviously longer in group C than that of group A and group B in first birth process(P<0.05). The volume of hemorrhage, the Apgar score, blood gas analysis of foetal umbilical artery, milk secretion and NACS had no difference in statistics(P>0.05). The adverse effect was obviously more in group A than that of group B(P<0.05).Conclusion: Comparing with epidural analgesia, PCIA with remifentanil has baddish effect major adverse adverse effect,has no effect on neonatus.The puerperal who refuse epidural analgesia and has contraindication of epidural analgesia was given PCIA with remifentanil.