Objective To explore the effect of long-term out-hospital care management on the quality of life in the eldly patients with coronary heart disease after PCI. Methods 138 eldly coronary heart disease patients received PCI(age>60y) were enrolled. All patients who have signed informed consent were randomized into the treatment group(72 cases) and the control group(66 cases). The control group received conventional discharge instruction, and the treatment group received long-term care management besides the conventional discharge instruction. The quality of life of the two groups were compared by common instrument SF-36 and special instrument SAQ when leave hospital and after 12 moths. Results The life quality score of the treatment group were higher than that in the control group after 12 months. Conclusion Long-term out-hospital care maybe improve the quality of life in the eldly patients with coronary heart disease after 12 moths of PCI.