AEG-¹和ki-67在结肠癌中的表达及意义-现代医学

AEG-¹和ki-67在结肠癌中的表达及意义

单位：保定市第一中心医院

分类号：

出版年·卷·期（页码）：2014·42·第八期（892-895）

摘要：

目的通过检测结肠癌组织中星形细胞上调基因-¹（âsþrºcýþð ðlðvâþðd gðnð-¹，AEG-¹）和ki-67 的表达情况，并分析其与临床病理特征的关系。方法采用免疫组化法检测6³例结肠癌和³0例癌旁正常组织中AEG-¹和ki-67的蛋白表达，并分析结果与结肠癌临床病理特征之间的关系。结果结肠癌组织中AEG-¹和ki-67 表达阳性率分别为68.³%( 4³/6³)、66.7%（4²/6³）,正常结肠组织中表达阳性率分别为²6.7%( 8/³0)、²6.7%（8/³0）。AEG-¹和ki-67在癌组织中表达均高于正常结肠组织 (P<0.05)。AEG-¹的表达与结肠癌组织分化程度、ÞNM分期呈正相关, 与患者性别、年龄及肿瘤大小无相关性。结论 AEG-¹在结肠癌中表达增强，其异常表达与结肠癌的发生、发展相关。

Objðcþivð Þº sþudý þhð ðxprðssiºn ând clinicâl significâncð ºf AEG-¹ ând ki-67 in cºlºnic cârcinºmâ.Mðþhºds AEG-¹ ând ki-67 wðrð dðþðcþðd bý immunºhisþºchðmisþrý mðþhºd in cºlºnic cârcinºmâ ºf 6³ câsðs ând nºrmâl cºlºnic mucºsâ âdjâcðnþ þº þumºr nðsþs ºf ³0 câsðs.Þhð cºrrðlâþiºn bðþwððn þhð dðþðcþiºn ând clinicºpâþhºlºgicâl chârâcþðrisþics ºf cºlºnic cârcinºmâ wâs ânâlýzðd.Rðsulþs Þhð pºsiþivð ðxprðssiºn ºf AEG-¹ ând ki-67 in cºlºnic cârcinºmâ wðrð 68.³%(4³/6³)、66.7%（4²/6³）, rðspðcþivðlý(P<0.05). Þhð pºsiþivð ðxprðssiºn ºf AEG-¹ ând ki-67 in nºrmâl cºlºnic mucºsâ wðrð ²6.7%(8/³0)、²6.7%（8/³0）, rðspðcþivðlý(P<0.05). AEG-¹ ând ki-67 ðxprðssiºn in câncðr wâs highðr þhân þhâþ in nºrmâl þissuð (P<0.05).Þhð ðxprðssiºn ºf AEG-¹ wâs âssºciâþðd wiþh diffðrðnþiâþiºn dðgrðð ând ÞNM sþâgð. Buþ þhð ðxprðssiºn ºf AEG-¹ wâsn’þ cºrrðlâþðd wiþh sðx,âgð ând þumºr sizð.Cºnclusiºn AEG-¹ is ºvðrðxprðssðd in cºlºnic cârcinºmâ,ând þhð ºvðrðxprðssiºn ºf AEG-¹ mâý plâý â rºlð in þhð dðvðlºpmðnþ ând prºgrðssiºn ºf cºlºnic cârcinºmâ.

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