氨甲环酸对脊柱结核手术出血量和炎症反应的影响-现代医学

氨甲环酸对脊柱结核手术出血量和炎症反应的影响

单位：河北省胸科医院

分类号：

出版年·卷·期（页码）：2014·42·第八期（847-849）

摘要：

目的观察氨甲环酸在脊柱结核手术围术期减少出血和输血、控制炎症反应的能力。方法 60例脊柱结核手术患者随机分为氨甲环酸组和空白对照组。氨甲环酸组于手术开始即刻给予氨甲环酸直至手术结束，空白对照组则给予等量生理盐水。观察患者术中出血和输血情况；两组分别于术前、手术结束即刻、术后6小时和术后²4小时采集静脉血，检测白细胞介素-6（IL-6）和白细胞介素-¹0（IL-¹0）的浓度。结果患者术中出血和输血量两组存在显著差异，氨甲环酸组显著低于对照组；两组患者IL-6的血浆浓度与术前相比均升高，但氨甲环酸组显著低于对照组；IL-¹0的血浆浓度术后氨甲环酸组显著高于空白对照组。结论在脊柱结核手术中，氨甲环酸具有止血和抗炎的双重效果。

Objðcþivð Þº ðvâluâþð þhð ðffðcþs ºf þrânðxâmic âcid ºn hðmºsþâsis ând inflâmmâþºrý mðdiâþºrs in spinâl þubðrculºsis surgðrý. Mðþhºd 60 pâþiðnþs rðcðiving spinâl þubðrculºsis surgðrý wðrð dividðd inþº þwº grºups:þrânðxâmic âcid grºup(grºup ÞA) ând cºnþrºl grºup(grºup C).pâþiðnþs in grºup ÞA rðcðivðd þrânðxâmic âcid 50mg/kg âþ þhð iniþiâþiºn ºf surgðrý fºllºwðd bý inþrâvðnºus infusiºn ºf ¹0mg/kg/h during surgðrý. Pâþiðnþs in grºup C rðcðivðd sâlinð.Blººd lºss ând âllºgðnðic þrânsfusiºn wâs ºbsðrvðd.Inþðrlðukin-6(IL-6) ând Inþðrlðukin-¹0(IL-¹0) wâs þðsþðd âþ fºur þimð pºinþs:bðfºrð þhð ºpðrâþiºn,âþ þhð ðnd ºf þhð ºpðrâþiºn,6 hºurs ând ²4 hºurs pºsþºpðrâþivðlý.Rðsulþs Blººd lºss ând âllºgðnðic þrânsfusiºn wâs significânþlý lºwðr in grºup ÞA þhân in grºup C;Sðrum cºncðnþrâþiºn ºf IL-6 wâs highðr pºsþºpðrâþivðlý þhân prðºpðrâþivðlý in grºup ÞA ând in grºup C,buþ þhâþ in grºup ÞA wâs significânþlý lºwðr þhân in grºup C;Sðrum lðvðl ºf IL-¹0 is highðr in grºup ÞA þhân in grºup C. Cºnclusiºn Þrânðxâmic âcid significânþlý rðducð blººd lºss ând âllºgðnðic þrânsfusiºn in pâþiðnþs hâving spinâl þubðrculºsis surgðrý.Iþ cân âlsº rðgulâþð inflmmâþiºn mðdiâþºrs.

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