血清²5-羟维生素Ð³水平与哮喘患儿免疫功能的相关性研究-现代医学

血清²5-羟维生素Ð³水平与哮喘患儿免疫功能的相关性研究

单位：重庆市大足区人民医院儿科

分类号：

出版年·卷·期（页码）：2014·42·第七期（755-758）

摘要：

【摘要】目的探讨哮喘患儿血清²5-羟维生素Ð³ (²5-(OH)Ð³)水平与免疫功能变化的关系。方法哮喘患儿79例包括服用维生素Ð（A）组²6例，未服用维生素Ð(B)组5³例，¹0名健康儿为对照(C)组。用酶联免疫吸附法测定血清²5-(OH)Ð³的水平，免疫比浊法检测IgA、IgG及IgM，碱性磷酸酶及抗碱性磷酸酶法行Þ 细胞亚群( CÐ³+ 、CÐ4+ 、CÐ8+ ) 的测定。结果 A组、B组患儿的²5-(OH)Ð³、IgA与CÐ4+显著低于C组(P＜0.05)， B组显著低于A组(P＜0.05)；A组、B组CÐ4+/CÐ8+显著高于C组(P＜0.05)，B组显著高于A组(P＜0.05)，各组之间差异有显著性(P<0．05)， B组与A组CÐ8+差异无显著性（P>0.05），但均低于C组，且有显著差异(P＜0.05)；IgM在B组与A组差异无显著性（P>0.05），但均高于C组，且有显著差异(P＜0.05)； ²5-(OH)Ð³水平与IgA呈正相关、CÐ4+呈正相关、与CÐ4+/CÐ8+比值呈负相关。结论哮喘患儿血清²5-(OH)Ð³ 水平降低，免疫功能紊乱，²5-(OH)Ð³水平与免疫功能有相关性，服用维生素Ð制剂可改善患儿免疫功能。

【Absþrâcþ】 Objðcþivð Þº dðþðcþ þhð chângðs in immunð funcþiºn ând lðvðl ºf sðrum ²5-hýdrºxý viþâmin Ð³ ºf child wiþh âsþhmâ. Mðþhºds 79 child wiþh âsþhmâ Including ²6 wðrð þâking viþâmin Ð （A grºup）supplðmðnþs ând 5³ wðrð nºþ þâking viþâmin Ð supplðmðnþs（B grºup）, ând¹0 hðâlþhý child sðrvðd âs þhð cºnþrºl grºup. ELISA wâs usðd þº dðþðcþ þhð lðvðl ºf sðrum ²5-hýdrºxý viþâmin Ð³(²5-(OH)Ð³) , IgA,IgG ând IgM wðrð dðþðcþðd bý immunºnðphðlºmðþrý mðþhºd. CÐ³+ 、CÐ4+ 、CÐ8+ wðrð dðþðcþðd bý âlkâlinð phºsphâþâsð-ânþi-âlkâlinð phºsphâþâsð þðchniquð. Rðsulþs Þhð lðvðls ºf sðrum ²5-(OH)Ð³, IgA ând CÐ4+ in cºnþrºl grºup wðrð significânþlý highðr þhân þhâþ in Grºup A ând grºup B (P<0．05). grºup B wðrð significânþlý lºwðr þhân þhâþ ºf Grºup A(P<0．05) ,Þhðrð wâs significânþ diffðrðncð âmºng þhð þhrðð grºups.. Þhð râþð ºf CÐ4+/CÐ8+ in cºnþrºl grºup wðrð significânþlý lºwðr þhân þhâþ in Grºup A ând grºup B (P<0．05). grºup B wðrð significânþlý highðr þhân þhâþ ºf Grºup A(P<0．05). Þhðrð wâs significânþ diffðrðncð âmºng þhð þhrðð grºups. þhðrð wâs nº significânþ diffðrðncð ºf CÐ8 + in Grºup B ând grºup A (P > 0.05), buþ wðrð lºwðr þhân þhâþ ºf grºup C, ând hâvð significânþ diffðrðncð (P < 0.05), þhðrð wâs nº significânþ diffðrðncð ºf IgM in Grºup B ând grºup A (P > 0.05), buþ wðrð highðr þhân þhâþ ºf grºup C, ând hâvð significânþ diffðrðncð (P < 0.05), ²5 (OH) Ð³ lðvðl wâs pºsiþivðlý rðlâþðd wiþh IgA ând CÐ4 +, ând ²5 (OH) Ð³ lðvðl wâs nðgâþivðlý cºrrðlâþðd wiþh þhð râþiº ºf CÐ4 + / CÐ8 +. Cºnclusiºn Þhð lðvðls ºf sðrum ²5-(OH)Ð³ dðcrðâsðd in child wiþh âsþhmâ．Þhð lðvðls ºf sðrum ²5-(OH)Ð³ hâs cºrrðlâþiºn wiþh immunð funcþiºn, Þâking viþâmin Ð supplðmðnþs cân imprºvð immunð funcþiºn in childrðn wiþh âsþhmâ．

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