【Abstract】 Objective To investigate the effects of general anesthesia with OPLAC laryngeal mask Airway ventilation combined continuous epidural anesthesia for high-risk elderly patients in lower abdominal and lower limb surgery. Methods 50 patients were randomly divided into two groups(n= 25):combined anesthesia group (Group A); intravenous anesthesia group (Group B). patients in group A were Administrated abdominal epidural block up to T10 induced with 0.33% Ropivacaine(5ml/h); general anesthesia with OPLAC laryngeal mask airway were induced with Midazolam(0.04mg• kg-1), Fentanyl(2~6ug• kg-1), Propofol(1~1.5 mg•kg-1) and Atracurium(0.1 mg• kg-1) intravenously and maintained with Propofol (50~100 ug•kg-1•min-1)and Remifentanil(0.05~0.5ug•kg-1•min-1), while patients in group B were induced the same drugs and procedures and maintained with Propofol (60~120 ug• kg-1•min-1)and Remifentanil(0.05~1ug• kg -1•min-1). hemodynamic parameters of Mean arterial pressure (MAP), heart rate (HR),pulse oxygen saturation (SpO2) at time of before induction (T0), after induction (T1), intubation (T2), 5 mins after intubation (T3), extubation (T4);Anesthetic drug dosage,awake time,extubation time, recovery Scale(Steward),and incidence of postoperative complications such as Nausea, vomiting were recoded. Results Compared with group B, the time of awake and extubation in group A were significantly decreased (P<0.05), and recovery Scale were significantly increased (P<0.05). Compared with group B, the stability of hemodynamic parameters of Mean arterial pressure (MAP), heart rate (HR),pulse oxygen saturation (SpO2) in group A were significantly increased (P<0.05), while Anesthetic drug dosage significantly decreased (P<0.05). Compared with group B, the incidence of postoperative complications in group A were significantly decreased (P<0.05). Conclusions general anesthesia combined c |