Objective To discuss the application of Mifepristone,and Misoprostol which used in many times and repeated painless surgical abortions ,observe the different using in effect of softening the cervical ,to promote the uterine contractions ,to reduce the intraoperative blood loss, to decrease of postoperative cervical adhesion and to shorten the time of bleeding after operation. Methods Three hundred cases of many times and repeated painless surgical abortions were divided into three groups:A group 100 cases used Mifepristone 100mg po at 8pm the day before operation, B group 100 cases used Misoprostol 400ug in vagine vault two hours before operation, C group 100 cases used Mifepristone 100mg po at 8pm the day before operation,and sublingual with Misoprostol 400ug two hours before operation. Observed the differences of the three methods in softening the cervical ,to promote the uterine contractions ,to reduce the intraoperative blood loss, observe anaesthesia effect and decrease of postoperative cervical adhesion and to shorten the time of bleeding after operation. Result Group A,B,C in softening the cervical , anaesthesia effect and decrease of postoperative cervical adhesion were no statistically significant(P>0.05), Group C in operation times,gastrointestinal discomfortable, intraoperative blood loss compared with groupA, B were statistically significant(P＜0.05), Group A in bleeding after operation compared with groupB ,Cwere statistically significant (P＜0.05). Conclusion To joint Mifepristone with Misoprostol used in many times and repeated painless surgical abortions, may reduce the intraoperative blood loss, reduce the operation times reduce the cervical lesions, increasing the safety of the anesthetic to shorten the time of bleeding after operation. This method is worthed to application and to promote to all surgical abortions which with high risks.