Objective: To investigate protective effect of intestinal mucosa of patients with loss compensatory stage of cirrhosis treated with Intestinal probiotics. Method: 82 cases of patient with loss compensatory stage of cirrhosis were selected and randomly divided into observation group and control group, in each group there were 41 cases, another normal group there 40 cases was set,control group were treated with conventional therapy, observation group were treated with intestinal probiotics on the base of control group, normal group were without any treatment,the intestinal permeability, ETX level，intestinal flora changes among three groups before and after treatment were compared .Result: before treatment, the LAC, LAC/MAN, ETX in observation group and control group were higher than the normal group,the MAN was lower than that of normal group (P<0.05),the intestinal Bifidobacterium, Lactobacillus, Bacteroides in observation group and control group were significantly lower than that in normal group, the clostridium, enterobacter, yeast-like fungi were increased markedly (P<0.05); after treatment，the LAC, LAC/MAN, ETX were lower than those in control group (P<0.05), the Bifidobacterium, Lactobacillus, Bacteroides, Enterococcus in observation group was significantly higher than those of control group,the intestinal bacteria, yeasts was significantly lower than those in control group (P<0.05). Conclusion: intestinal probiotics can significantly improve the intestinal permeability of patients with loss compensatory stage of cirrhosis，reduce production of ETX, at the same time, improve intestinal flora microecology balance, repair intestinal mucosa barrier, and then improve patient’s prognosis, it is worthy of clinical application.