【Abstract】Objective To assess the incidence of gastric cancer development in gastric benign ulcer patients by periodically taking specimens from both the edges and base of healing or complete healing benign gastric ulcers in contrast to the traditional biopsy which takes specimens from the edges of ulcers only and abandons a biopsy after inprovement. Methods An endoscopic follow-up was conducted on 456 gastric ulcer patients in our hospital which are grouped.We collected clinical, endoscopic and pathological data and assessed H. pylori infection.Results Gastric cancers developed in 11 (2.41%) of 456 GU patients. In the experimental group, 3 cases were diagnosed by taking specimens from the ulcer bases and in the other 5 cases the specimens were taken from the ulcer edges. The detection rate of gastric cancer from gastric ulcer between experimental group and control group was statistically significant (p=0.04, p<0.05). Conclusion More early gastric cancers may be found out by periodically biopsies from both the edges and base of healing or complete healing benign gastric ulcers with H. pylori.